• Publications
  • Influence
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
TLDR
The results demonstrate the existence of a nuclear receptor signalling pathway for oxysterols and suggest that LXRα may be important as a sensor of cholesterol metabolites. Expand
Targeting QseC Signaling and Virulence for Antibiotic Development
TLDR
Using a high-throughput screen, a small molecule is identified that inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibitingQseC-mediated activation of virulence gene expression, markedly inhibits the virulence of several pathogens in vitro and in vivo in animals. Expand
Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors.
TLDR
Inhibition of microsomal activity by PPOH, but not DDMS, was time- and NADPH-dependent, a result characteristic of a mechanism-based irreversible inhibitor, which provides information useful for evaluating the role of the CYP-derived arachidonic acid metabolites in the regulation of renal function and blood pressure. Expand
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.
TLDR
The data indicate a central role for EETs in tumorigenesis, offering a mechanistic link between lipid signaling and cancer and emphasizing the critical importance of considering possible effects of EET-modulating drugs on cancer. Expand
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension
TLDR
It is concluded that the androgen-mediated regulation of Cyp 4a arachidonate monooxygenases is an important component of the renal mechanisms that control systemic blood pressures. Expand
Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor α
TLDR
It is shown here that P450 eicosanoids can bind to and activate PPARα and result in the modulation of PPAR α target gene expression, and pharmacological modulation of their formation and/or degradation may yield therapeutic benefits. Expand
Inhibition of Cytochrome P450&ohgr;-Hydroxylase: A Novel Endogenous Cardioprotective Pathway
TLDR
An important endogenous role for CYP&ohgr;-hydroxylases and in particular their product, 20-HETE, in exacerbating myocardial injury in canine myocardium is indicated. Expand
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.
TLDR
The results indicate the production of 20-HETE is elevated in the cerebral vasculature of SHRSP and contributes to oxidative stress, endothelial dysfunction, and the enhanced sensitivity to ischemic stroke in this hypertensive model. Expand
Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic β Cells
TLDR
Maintenance of high concentrations of IP7 in the pancreatic β cell may enhance the immediate exocytotic capacity and consequently allow rapid adjustment of insulin secretion in response to increased demand. Expand
Actions of epoxygenase metabolites on the preglomerular vasculature.
TLDR
Results indicate that the preglomerular vasoconstriction to 5,6-E ET is cyclooxygenase dependent and requires an intact endothelium, whereas the vasodilation to 11,12-EET is stereoselective and is the result of direct action of the epoxide on the preglomerular vascular smooth muscle. Expand
...
1
2
3
4
5
...