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beta-lapachone

Known as: 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione, Lapachone, b-Lapachone 
A poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. Beta-lapachone (b-lap) is bioactivated by NAD(P)H… 
National Institutes of Health

Related topics

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ARQ 501

Broader (4)

Anti-Infective AgentsNaphthoquinonesRadiation-Sensitizing AgentsReverse Transcriptase Inhibitors
NCIt Antineoplastic Agent Terminology

Papers overview

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2019
2019
The administration of ß-lapachone reverts inflammation and improves cartilage regeneration in an ex vivo model of OA
Poster.-- Tisssue Engineering Therapies: From Concept to Clinical Translation & Commercialisation (TERMIS), 27-31 May 2019… 
2017
2017
Effect of -lapachone on hydrogen peroxide production in "Trypanosoma cruzi"
Summary /?-Lapachone, an antimicrobial agent, markedly increase the generation of H202 in intact Trypanosoma cruzi épimastigotes… 
2017
2017
Mitochondrial DNA mutations are involved in the development of childhood myelodysplastic syndrome
1 Adaptation of hypoxia and mitochondrial metabolism in breast cancer in response to Avastin and metformin 
2015
2015
Assesment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice
Patients affected by cutaneous leishmaniasis need a topical treatment which cures lesions without leaving scars. Lesions are… 
2013
2013
Magainin, isolated from Xenopus laevis, induced Apoptosis in Human Cervical Carcinoma Cells
Magainins are a family of potent antimicrobial cationic peptides that possess antimicrobial activity, anti-tumour activity… 
2013
2013
Abstract 3344: Inhibiting base excision repair synergistically enhances beta-lapachone-mediated ‘kiss of death’ for tumor-selective therapy of pancreatic cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Pancreatic cancer will be the second leading cause… 
2012
2012
Therapeutics , Targets , and Chemical Biology An NQO 1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP 1-Induced Programmed Necrosis
Agents, such as b-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis… 
2011
2011
Cancer Therapy : Preclinical Modulating Endogenous NQO 1 Levels Identifies Key Regulatory Mechanisms of Action of b-Lapachone for Pancreatic Cancer Therapy
Purpose: Pancreatic cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less than 5… 
2002
2002
Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
The present invention demonstrates the nearly insoluble β- Rapa cone represents a significant antineoplastic activity against… 
1979
1979
Microbial Transformations ofNatural Antitumor Agents: Conversion ofLapachol toDehydro-a-Lapachone
which was isolated andcharacterized bynuclear magnetic resonanceandmass spectral analyses; its structure was verified bychemical…