beta-lapachone

Known as: 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione, Lapachone, b-Lapachone 
A poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. Beta-lapachone (b-lap) is bioactivated by NAD(P)H… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non… (More)
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2007
2007
Beta-lapachone (beta-lap) is a novel anticancer agent that is bioactivated by NADP(H): quinone oxidoreductase 1 (NQO1), an enzyme… (More)
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Highly Cited
2003
Highly Cited
2003
Most chemotherapeutic drugs kill cancer cells by indirectly activating checkpoint-mediated apoptosis after creating nonselective… (More)
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Review
2002
Review
2002
Beta-lapachone is an ortho naphthoquinone, originally isolated from a tree whose extract has been used medicinally for centuries… (More)
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Highly Cited
2001
Highly Cited
2001
beta-Lapachone (beta-Lap) triggers apoptosis in a number of human breast and prostate cancer cell lines through a unique… (More)
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Highly Cited
2000
Highly Cited
2000
beta-Lapachone activates a novel apoptotic response in a number of cell lines. We demonstrate that the enzyme NAD(P)H:quinone… (More)
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Highly Cited
1997
Highly Cited
1997
Recent studies have suggested that 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (beta-lapachone) inhibits DNA… (More)
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Highly Cited
1995
Highly Cited
1995
beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form… (More)
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Highly Cited
1993
Highly Cited
1993
beta-Lapachone is a plant product that has been found to have many pharmacological effects. To date, very little is known about… (More)
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1984
1984
In order to find a 3,4-dihydro-2H-naphtho[1,2-b]pyran-5,6-dione more potent than the naturally occurring 2,2-dimethyl derivative… (More)
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