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beta-lapachone

Known as: 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione, Lapachone, b-Lapachone 
A poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. Beta-lapachone (b-lap) is bioactivated by NAD(P)H… 
National Institutes of Health

Related topics

Related topics

6 relations

Narrower (1)

ARQ 501

Broader (4)

Anti-Infective AgentsNaphthoquinonesRadiation-Sensitizing AgentsReverse Transcriptase Inhibitors
NCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2006
Highly Cited
2006
Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase.
The DNA topoisomerase inhibitor beta-lapachone is a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in… 
2006
2006
Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation.
Beta-lapachone (beta-lap) is a novel anticancer agent that kills tumors overexpressing the NADPH: quinone oxidoreductase enzyme… 
Highly Cited
2005
Highly Cited
2005
Development of β-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels
β-Lapachone, an o-naphthoquinone, induces a novel caspase- and p53-independent apoptotic pathway dependent on NAD(P)H:quinone… 
Highly Cited
2005
Highly Cited
2005
Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity.
The objective of the present study was to investigate the effect of beta-lapachone, a quinone obtained from the bark of the… 
Review
2002
Review
2002
Cancer therapy with beta-lapachone.
Beta-lapachone is an ortho naphthoquinone, originally isolated from a tree whose extract has been used medicinally for centuries… 
Review
2001
Review
2001
[Cytotoxicity of beta-lapachone, an naphthoquinone with possible therapeutic use].
beta-lapachone (beta-lap) is a lipophilic o-naphthoquinone isolated from the bark of the lapacho tree. Initial observations… 
Highly Cited
1996
Highly Cited
1996
Redox cycling of o-naphthoquinones in trypanosomatids. Superoxide and hydrogen peroxide production.
1984
1984
β-Lapachone greatly enhances MMS lethality to human fibroblasts
Highly Cited
1978
Highly Cited
1978
Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi.
Addition of beta-lapachone, an o-naphthoquinone endowed with trypanocidal properties to respiring Trypanosoma cruzi epimastigotes… 
1978
1978
Generation of Superoxide Anions and Hydrogen Peroxide from β-Lapachone in Bacteria
β-Lapachone markedly increased the generation of superoxide anions and hydrogen peroxide by subcellular membranes of Bacillus… 
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