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beta Lactamase Inhibitors [MoA]

Known as: beta Lactamase Inhibitors, beta-Lactamase Inhibitors 
National Institutes of Health

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ClavulanateSulbactamSulbactam Sodiumavibactam

Papers overview

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Review
2010
Review
2010
Inhibitor-based methods for the detection of KPC carbapenemase-producing Enterobacteriaceae in clinical practice by using boronic acid compounds.
Enterobacteriaceae clinical strains that produce the class A carbapenem-hydrolysing enzyme KPC (Klebsiella pneumoniae… 
2007
2007
Screening of some medicinal plants from cameroon for β‐Lactamase inhibitory activity
In efforts to find new bioactive β‐lactamase inhibitors, this study investigated 16 Cameroonian plants belonging to 10 families… 
2006
2006
Synthesis and evaluation of ketophosph(on)ates as beta-lactamase inhibitors.
A series of amidoketophosph(on)ates of general structure PhCH2OCONHCH(R)COCHR'(CH2)n(O)P(O2-)(O)R'' (R = H, CH3; R' = H, CH3; n… 
2001
2001
Design, synthesis, and evaluation of alpha-ketoheterocycles as class C beta-lactamase inhibitors.
A series of specific alpha-ketoheterocycles (benzoxazole, thiazole, imidazole, tetrazole, and thiazole-4-carboxylate) has been… 
1999
1999
The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors.
Penicillin sulfones, which structurally incorporate both a 6-position alkylidene substituent and a 2'beta substituent, have been… 
1998
1998
Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.
A series of bridged monocyclic beta-lactams activated by various groups on the beta-lactam nitrogen (X = OCH2CO2H, OSO3H) has… 
1993
1993
(6R)-6-(substituted methyl)penicillanic acid sulfones: new potent beta-lactamase inhibitors.
A series of (6R)-6-(substituted methyl)penicillanic acid sulfones has been prepared starting from the corresponding 6… 
1989
1989
Diketene analogs as beta-lactamase inhibitor.
Compounds having a structural analogy with diketene have been synthesized and their potencies as beta-lactamase inhibitors have… 
1987
1987
Structure-activity relationships of 6-(heterocyclyl)-methylene penam sulfones; a new class of beta-lactamase inhibitors.
6-(Heterocyclyl)methylene penam sulfones (1) are effective beta-lactamase inhibitors and potent ampicillin and cefazolin… 
Review
1980
Review
1980
[beta-lactamase inhibitors].
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