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Normal cells can permanently lose the ability to proliferate when challenged by potentially oncogenic stress, a process termed… Expand Replicative senescence limits the proliferation of somatic cells passaged in culture and may reflect cellular aging in vivo. The… Expand The primary circadian pacemaker, in the suprachiasmatic nucleus (SCN) of the mammalian brain, is photoentrained by light signals… Expand ABSTRACT The synthetic peptide T-20 (enfuvirtide) represents the first of a new class of antiretroviral compounds to demonstrate… Expand Circulating endothelial progenitor cells (EPCs) have been isolated in peripheral blood of adult species. To determine the origin… Expand Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative… Expand Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of… Expand We have constructed a HeLa cell line that both expresses high levels of CD4 and contains a single integrated copy of a beta… Expand RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were… Expand Two yeast/E. coli shuttle vectors have been constructed. The two vectors, YEp351 and YEp352, have the following properties: (1… Expand