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Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN.
Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan.
Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
Diabetes and the Accompanying Hyperglycemia Impairs Cardiomyocyte Calcium Cycling through Increased Nuclear O-GlcNAcylation*
The results suggest that the hexosamine pathway, and O-GlcNAcylation in particular, is important in impaired cardiac myocyte function and the development of diabetic cardiomyopathy.
Arbutin: mechanism of its depigmenting action in human melanocyte culture.
The results suggest that the depigmenting mechanism of arbutin in humans involves inhibition of melanosomal tyrosinase activity, rather than suppression of the expression and synthesis of tyrosIn enzyme, which is effective in the topical treatment of various cutaneous hyperpigmentations characterized by hyperactive melanocyte function.
Molecular Cloning and Expression of a Novel β-1,6-N-Acetylglucosaminyltransferase That Forms Core 2, Core 4, and I Branches*
The results indicate that the newly cloned C2GnT-M plays a critical role inO-glycan synthesis in mucins and might have distinctly different roles in oligosaccharide ligand formation compared with C2NgT-L.
Sialyltransferase ST8Sia-II Assembles a Subset of Polysialic Acid That Directs Hippocampal Axonal Targeting and Promotes Fear Behavior*
Genetic partitioning of PSA formation engenders discrete neurological processes and reveals that this post-translational modification forms the predominant basis for the multiple functions attributed to the NCAM glycoprotein.
Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule.
Molecular Cloning and Expression of Two Distinct Human Chondroitin 4-O-Sulfotransferases That Belong to the HNK-1 Sulfotransferase Gene Family*
- N. Hiraoka, H. Nakagawa, E. Ong, T. Akama, M. Fukuda, M. Fukuda
- Biology, ChemistryThe Journal of Biological Chemistry
- 30 June 2000
Northern analysis demonstrated that the transcript for C4 ST-1 is predominantly expressed in peripheral leukocytes and hematopoietic tissues while theC4ST-2 transcript is more widely expressed in various tissues, indicating C4STs play complementary roles in chondroitin and dermatan sulfate synthesis in different tissues.
The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells
IgA1 protease cleavage of LAMP1 promotes intracellular survival of pathogenic Neisseria spp.