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Sialyltransferase ST8Sia-II Assembles a Subset of Polysialic Acid That Directs Hippocampal Axonal Targeting and Promotes Fear Behavior*
Genetic partitioning of PSA formation engenders discrete neurological processes and reveals that this post-translational modification forms the predominant basis for the multiple functions attributed to the NCAM glycoprotein. Expand
Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN. Expand
Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
It is indicated that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation. Expand
Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan.
Results indicate that the two lysosomal membrane glycoproteins purified from chronic myelogenous leukemia cells are extensively modified by N-glycans, and some of these were found to have polylactosaminyl repeats and sialic acid. Expand
Diabetes and the Accompanying Hyperglycemia Impairs Cardiomyocyte Calcium Cycling through Increased Nuclear O-GlcNAcylation*
The results suggest that the hexosamine pathway, and O-GlcNAcylation in particular, is important in impaired cardiac myocyte function and the development of diabetic cardiomyopathy. Expand
Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule.
The presence of polysialic acid is always associated with expression of ST8Sia II and/or IV, suggesting that ST8 sialic Acid II and IV are the key enzymes that control the expression ofpolysIALic acid. Expand
Molecular Cloning and Expression of a Novel β-1,6-N-Acetylglucosaminyltransferase That Forms Core 2, Core 4, and I Branches*
The results indicate that the newly cloned C2GnT-M plays a critical role inO-glycan synthesis in mucins and might have distinctly different roles in oligosaccharide ligand formation compared with C2NgT-L. Expand
Molecular Cloning and Expression of Two Distinct Human Chondroitin 4-O-Sulfotransferases That Belong to the HNK-1 Sulfotransferase Gene Family*
Northern analysis demonstrated that the transcript for C4 ST-1 is predominantly expressed in peripheral leukocytes and hematopoietic tissues while theC4ST-2 transcript is more widely expressed in various tissues, indicating C4STs play complementary roles in chondroitin and dermatan sulfate synthesis in different tissues. Expand
Arbutin: mechanism of its depigmenting action in human melanocyte culture.
  • K. Maeda, M. Fukuda
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 February 1996
The results suggest that the depigmenting mechanism of arbutin in humans involves inhibition of melanosomal tyrosinase activity, rather than suppression of the expression and synthesis of tyrosIn enzyme, which is effective in the topical treatment of various cutaneous hyperpigmentations characterized by hyperactive melanocyte function. Expand
The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells
IgA1 protease cleavage of LAMP1 promotes intracellular survival of pathogenic Neisseria spp. Expand