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Age-related skeletal muscle dysfunction is the underlying cause of morbidity that affects up to half the population aged 80 and… (More)

OBJECTIVES Anaplastic thyroid carcinomas (ATC) are highly aggressive tumours unresponsive to any available radio- or… (More)

The introduction of the tyrosine kinase inhibitor (TKI), imainib mesylate, has revolutionized the treatment of chronic myeloid… (More)

Activation of the cannabinoid type 1 (CB1) receptor, a major G-protein-coupled receptor in brain, acts to regulate neuronal… (More)

Dear Editor: Imanitib mesylate is a selective inhibitor of the BCR-ABL tyrosine kinase and has been used as an effective therapy… (More)

Gastrointestinal stromal tumors GIST are rare mesenchymal tumors of the gastrointestinal tract characterized by expression of a… (More)

Mutations in transcription factors (TFs) and protein tyrosine kinases (PTKs), which result in inhibition of differentiation… (More)

Agonist efficacy may influence the magnitude of neuroadaptation in response to chronic drug exposure. Chronic administration of… (More)

We have previously reported that the synthetic cannabinoid R-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1… (More)

The effects of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4- benzoxazin-yl]-(1-napthalenyl)methanone… (More)