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Histamine and its receptors
The discovery of nonimidazole derivatives such as brain‐penetrating H3 antagonists has provided drugs that are in early‐phase clinical trials, possibly for application in obesity, and a variety of central nervous system disorders, such as memory, learning deficits and epilepsy.
GABA(B) receptor function in the ileum and urinary bladder of wildtype and GABA(B1) subunit null mice.
- G. Sanger, M. Munonyara, N. Dass, H. Prosser, M. Pangalos, M. Parsons
- BiologyAutonomic & autacoid pharmacology
- 1 June 2002
The data suggest that, as in the central nervous system (CNS), the GABA(B1) receptor subunit is an essential requirement for GABA (B) receptor function in the enteric and PNS, and does not provide a structural explanation for the existence of putative subtypes of GABA( B) receptor.
Chemical differentiation of histamine H1- and H2-receptor agonists.
- G. J. Durant, C. Ganellin, M. Parsons
- Biology, ChemistryJournal of medicinal chemistry
- 1 September 1975
2-(2-aminoethyl)thiazole and 2-aminosine are nontautomeric and are highly selective agonists for histamine H1 receptors (H1:H2 ca. 90:1 and 30:1, respectively).
A role for histamine and H2-receptors in opioid antinociception.
It is suggested that stimulation of opioid receptors leads to antinociception by mechanisms that include activation of brain H2-receptors, and Cimetidine, unlike other H2 antagonists, potentiated MOR antinOCiception, potentiate opioid FSIA and increased brain MOR levels, actions that are not likely to be due to blockade of H1-receptor activity.
Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.
An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease
- A. Sykes, C. Brampton, S. Klee, C. Chander, C. Whelan, M. Parsons
- Medicine, BiologyInflammation Research
- 1 July 2000
Nicotine reduced inflammation in the TNBS model of colonic damage confirming the use of nicotine in IBD although the choice of dose requires further investigation.
Pharmacological aspects of acid secretion
The finding that H2-receptor antagonists are able to reduce or abolish acid secretion due to vagal, gastrinergic, and histaminergic stimulation shows that histamine plays a pivotal role in stimulation of the parietal cell.
CHEMICAL DIFFERENTIATION OF HISTAMINE H1- AND H2-RECEPTOR AGONISTS
Pharmacology of Histamine Receptors
3‐Aminopropylphosphinic acid—a potent, selective GABAB receptor agonist in the guinea‐pig ileum and rat anococcygeus muscle
- J. Hills, Rhona A. Dingsdale, M. Parsons, R. Dolle, W. Howson
- Chemistry, BiologyBritish journal of pharmacology
- 1 August 1989
It is concluded that 3‐aminopropylphosphinic acid is a potent, selective GABAB agonist, being seven times more potent than baclofen in the guinea‐pig ileum and five times more powerful in the rat anococcygues muscle preparations.