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benzo(a)pyrene-3,6-quinone

Known as: benzo(a)pyrene-3,6-dione 
National Institutes of Health

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Broader (1)

Benzopyrenes

Papers overview

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2001
2001
Intestinal bioavailability and biotransformation of 3-hydroxybenzo(a)pyrene in an isolated perfused preparation from channel catfish, Ictalurus punctatus.
The intestinal bioavailability and biotransformation of 3-hydroxybenzo(a)pyrene, a major metabolite of benzo(a)pyrene in many… 
Highly Cited
2000
Highly Cited
2000
Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity.
Highly Cited
1998
Highly Cited
1998
NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.
The role of microsomal NADPH:cytochrome P450 reductase (P450 reductase) and cytosolic NAD(P)H:quinone oxidoreductase 1 (NQO1 or… 
Highly Cited
1998
Highly Cited
1998
Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis.
Benzo(a)pyrene and benzene are human carcinogens. The metabolic activation of these compounds into ultimate mutagenic and… 
Review
1990
Review
1990
Induction of drug-metabolizing enzymes by xenobiotics.
1. Isozymes of the cytochromes P-450, UDP-glucuronosyl transferases (UDPGT) and glutathione S-transferases appear to be… 
1985
1985
Protection against toxic redox cycles between benzo(a)pyrene-3,6-quinone and its quinol by 3-methylcholanthrene-inducible formation of the quinol mono- and diglucuronide.
Cytotoxic effects of quinones are thought to be mediated by redox cycles between quinones and quinols whereby reactive oxygen… 
1985
1985
Induction of cell damage by menadione and benzo(a)pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblasts.
1985
1985
Relationship between the rate of reduction of benzo(a)pyrene-3,6-quinone and the formation of benzo(a)pyrene-3,6-quinol glucuronides in rat liver microsomes.
Highly Cited
1978
Highly Cited
1978
Metabolism of benzo(a)pyrene-3,6-quinone and 3-hydroxybenzo(a)pyrene in liver microsomes from 3-methylcholanthrene-treated rats. A possible role of DT-diaphorase in the formation of glucuronyl…
1978
1978
The existence of a benzo(a)pyrene-3,6-quinone reductase in rat liver microsomal fractions.
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