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benzene oxide

Known as: 7-oxabicyclo(4.1.0)hepta-2,4-diene 
National Institutes of Health

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Broader (1)

Cyclohexanes

Papers overview

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Review
2005
Review
2005
Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity.
2005
2005
Reactions of benzene oxide with thiols including glutathione.
S-Phenylmercapturic acid is a minor metabolite of benzene used as a biomarker for human benzene exposures. The reaction of… 
Highly Cited
2004
Highly Cited
2004
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation.
p-Hydroxyphenylpyruvate dioxygenase (HPD) plays a key role in the normal catabolism of tyrosine. An Fe2+/oxygen-dependent enzyme… 
Highly Cited
1998
Highly Cited
1998
Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene.
Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb… 
Highly Cited
1998
Highly Cited
1998
Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood.
Little is known about the formation and disposition of benzene oxide (BO), the initial metabolite arising from oxidation of… 
1996
1996
Analysis of hemoglobin adducts of benzene oxide by gas chromatography-mass spectrometry.
A method is reported for measuring cysteinyl adducts of the benzene metabolite benzene oxide (BO) with hemoglobin (Hb) in blood… 
Highly Cited
1996
Highly Cited
1996
The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives
Abstract CYP2B1 and 2E1 oxidized toluene, aniline and monochlorobenzene (MCB) to water-soluble metabolites and to products… 
Highly Cited
1994
Highly Cited
1994
Comparison of protein adducts of benzene oxide and benzoquinone in the blood and bone marrow of rats and mice exposed to [14C/13C6]benzene.
Protein binding of hemoglobin (Hb) and bone marrow was used to compare in vivo reactions of 3 electrophilic metabolites of… 
1993
1993
Biomarkers of human exposure to benzene.
Three biomarkers for benzene exposure were developed. The first biomarker, muconic acid in urine, results from the ring opening… 
Review
1981
Review
1981
Muconaldehyde, a potential toxic intermediate of benzene metabolism.
The metabolite of benzene that is responsible for its hematological toxicity is unknown. Benzene is of course the parent aromatic… 
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