Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
- Justin J. J. Leahy, B. Golding, G. Smith
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 20 December 2004
Metagenomic analysis and metabolite profiling of deep–sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill
- Nikole E. Kimes, A. V. Callaghan, P. J. Morris
- Environmental ScienceFrontiers in Microbiology
- 15 March 2013
The hypothesis that increased hydrocarbon exposure results in an altered sediment microbial community structure that reflects the prospects for oil biodegradation under the prevailing conditions is examined and increased exposure to hydrocarbons enriches Deltaproteobacteria, which are known to be capable of anaerobic hydrocarbon metabolism.
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
- C. E. Arris, F. Boyle, W. Yu
- Biology, ChemistryJournal of Medicinal Chemistry
- 11 July 2000
CDK inhibition and chemosensitivity data indicate that the distinct mode of binding of NU2058 and NU6027 has direct consequences for enzyme and cell growth inhibition.
2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
- J. J. Hollick, B. Golding, R. Griffin
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 15 September 2003
Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.
- Marc Hetzel, M. Brock, T. Selmer, A. Pierik, B. Golding, W. Buckel
- Biology, Computer ScienceEuropean Journal of Biochemistry
- 1 March 2003
Acryloyl-CoA reductase from Clostridium propionicum has been characterized as a soluble enzyme, with kinetic properties perfectly adapted to the requirements of the organism.
Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment
Investigations funded by the Deutsche Forschungsgemeinschaft on the anaerobic microbial degradation of hydrocarbons ranged from isolation and enrichment of hitherto unknown hydrocarbon-degrading anaerobe microorganisms, discovery of novel reactions, detailed studies of enzyme mechanisms and structures to process-oriented in situ studies.
Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
- I. Hardcastle, X. Cockcroft, R. Griffin
- Chemistry, BiologyJournal of Medicinal Chemistry
- 29 October 2005
Structure-activity relationships for inhibition of DNA-dependent protein kinase (DNA-PK) have been defined and a number of 7-alkoxy-substituted chromen-4-ones displayed improved activity.
Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer
- Kelly Coffey, T. Blackburn, C. Robson
- Biology, MedicinePLoS ONE
- 8 October 2012
Based on the activity of NU9056 and the specificity of the compound towards Tip60 relative to other HAT enzymes, these chemical biology studies have identified Tip60 as a potential therapeutic target for the treatment of prostate cancer.
Molecular hijacking of siroheme for the synthesis of heme and d1 heme
- Shilpa Bali, A. Lawrence, M. Warren
- ChemistryProceedings of the National Academy of Sciences
- 3 October 2011
A further branch of the modified tetrapyrrole biosynthesis pathway is described in denitrifying and sulfate-reducing bacteria as well as the Archaea and the evolutionary significance of another role for siroheme is examined.
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation
- M. Pennati, A. Campbell, D. Newell
- BiologyMolecular Cancer Therapeutics
- 1 September 2005
Results from this study indicate that NU6140 significantly potentiates the apoptotic effect of paclitaxel, with inhibition of survivin expression/phosphorylation as the potential mechanism.
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