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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted chromenone libraries, which were screened as inhibitors of the DNA repairExpand
Metagenomic analysis and metabolite profiling of deep–sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill
TLDR
The hypothesis that increased hydrocarbon exposure results in an altered sediment microbial community structure that reflects the prospects for oil biodegradation under the prevailing conditions is examined and increased exposure to hydrocarbons enriches Deltaproteobacteria, which are known to be capable of anaerobic hydrocarbon metabolism. Expand
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
TLDR
CDK inhibition and chemosensitivity data indicate that the distinct mode of binding of NU2058 and NU6027 has direct consequences for enzyme and cell growth inhibition. Expand
2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
TLDR
Members of both structural classes were found to be selective inhibitors of DNA-PK over related phosphatidylinositol 3-kinase-related kinase (PIKK) family members. Expand
Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
TLDR
Structure-activity relationships for inhibition of DNA-dependent protein kinase (DNA-PK) have been defined and a number of 7-alkoxy-substituted chromen-4-ones displayed improved activity. Expand
Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.
TLDR
Acryloyl-CoA reductase from Clostridium propionicum has been characterized as a soluble enzyme, with kinetic properties perfectly adapted to the requirements of the organism. Expand
Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment
TLDR
Investigations funded by the Deutsche Forschungsgemeinschaft on the anaerobic microbial degradation of hydrocarbons ranged from isolation and enrichment of hitherto unknown hydrocarbon-degrading anaerobe microorganisms, discovery of novel reactions, detailed studies of enzyme mechanisms and structures to process-oriented in situ studies. Expand
Molecular hijacking of siroheme for the synthesis of heme and d1 heme
TLDR
A further branch of the modified tetrapyrrole biosynthesis pathway is described in denitrifying and sulfate-reducing bacteria as well as the Archaea and the evolutionary significance of another role for siroheme is examined. Expand
Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer
TLDR
Based on the activity of NU9056 and the specificity of the compound towards Tip60 relative to other HAT enzymes, these chemical biology studies have identified Tip60 as a potential therapeutic target for the treatment of prostate cancer. Expand
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