benralizumab

Known as: BIW-8405, MEDI-563, Anti-CD125 Humanized Monoclonal Antibody, IgG1-kappa 
An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity… (More)

Topic mentions per year

Topic mentions per year

2010-2018
05101520102018

Papers overview

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2017
2017
BACKGROUND Many patients with severe asthma rely on oral glucocorticoids to manage their disease. We investigated whether… (More)
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2016
2016
BACKGROUND Benralizumab is a humanised, afucosylated, anti-interleukin-5 receptor α monoclonal antibody that induces direct… (More)
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2016
2016
BACKGROUND Eosinophilia is associated with worsening asthma severity and decreased lung function, with increased exacerbation… (More)
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2016
2016
BACKGROUND Airway eosinophils are considered to play an important role in the pathogenesis of asthma. Interleukin-5 is believed… (More)
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2015
2015
BACKGROUND Patients with frequent asthma exacerbations resulting in emergency department (ED) visits are at increased risk for… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Persistent eosinophilic airway inflammation in asthma increases the risk of exacerbations. In a phase 2b dose-ranging… (More)
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2014
2014
BACKGROUND Chronic obstructive pulmonary disease (COPD) is associated with eosinophilic airway inflammation in 10-20% of patients… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Many asthmatic patients exhibit sputum eosinophilia associated with exacerbations. Benralizumab targets eosinophils by… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Peripheral blood eosinophilia and lung mucosal eosinophil infiltration are hallmarks of bronchial asthma. IL-5 is a… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Increased eosinophil levels have been linked to airway inflammation and asthma exacerbations. IL-5 is responsible for… (More)
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