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Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study.
- M. Castro, S. Mathur, P. Nair
- MedicineAmerican journal of respiratory and critical care…
- 15 November 2011
Patients receiving reslizumab showed significantly greater reductions in sputum eosinophils, improvements in airway function, and a trend toward greater asthma control than those receiving placebo.
Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop
Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway
The downstream effect of HSF2 activation by proteasome inhibitors is the induction of the same set of heat shock genes that are induced during heat shock by HSF1, thus revealing that HSF 2 affords the cell with a novel heat shock gene-regulatory mechanism to respond to changes in the protein-degradative machinery.
Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2
- A. Mathew, S. Mathur, C. Jolly, S. Fox, Soojin Kim, R. Morimoto
- BiologyMolecular and Cellular Biology
- 1 November 2001
It is shown, using a novel DNA binding and detection assay, that HSF1 and HSF2 are coactivated to different levels in response to a range of conditions that cause cell stress and suggests a role for heat shock proteins in the positive regulation of HSF 2.
Novel targeted therapies for eosinophilic disorders.
Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.
- L. Denlinger, R. Sorkness, N. Jarjour
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 1 November 2011
Evaluating viral strain and load in a prospective asthma cohort during a natural cold suggests differential lower airway sensitization to the effects of neutrophilic inflammation in the patients having exacerbations.
Age-related changes in immune function: effect on airway inflammation.
Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock
- C. Marcuccilli, S. Mathur, R. Morimoto, R. Miller
- BiologyThe Journal of neuroscience : the official…
- 15 January 1996
The inability of primary cultured rat hippocampal neurons to induce a heat shock response after hyperthermia is demonstrated and considerations of selective neuronal vulnerability to environmental stress should include the principal mediators of the stress response, the HSF.
Surfing for Scoliosis: The Quality of Information Available on the Internet
The information about scoliosis on the Internet is of limited quality and poor information value, and the physician must assume primary responsibility of educating and counseling their patients.
Aggressive fibromatosis from infancy to adolescence.
It is suggested that conservative surgery with the goal of a wide margin coupled with adjuvant therapies may result in adequate control of disease from infancy to adolescence.