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azidopine

Known as: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-, 2-((4-azidobenzoyl)amino)ethyl ethyl ester 
 
National Institutes of Health

Papers overview

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Highly Cited
1995
Highly Cited
1995
Identifying new chemotherapeutic agents and characterizing mechanisms of resistance may improve cancer treatment. The Anticancer… Expand
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Highly Cited
1992
Highly Cited
1992
We expressed human MDR1 cDNA isolated from the human adrenal gland in porcine LLC-PK1 cells. A highly polarized epithelium formed… Expand
Highly Cited
1992
Highly Cited
1992
To determine the number of drug binding sites that exist on the multidrug transporter, P-glycoprotein, we used azidopine, a… Expand
Highly Cited
1991
Highly Cited
1991
  • I. Tamai, A. Safa
  • The Journal of biological chemistry
  • 1991
  • Corpus ID: 22306445
It is believed that P-glycoprotein (P-gp) is an energy-dependent drug efflux pump responsible for decreased drug accumulation in… Expand
Highly Cited
1991
Highly Cited
1991
To identify the binding domain for dihydropyridine Ca2+ antagonists, skeletal muscle Ca2+ channels were photolabeled with [3H… Expand
Highly Cited
1991
Highly Cited
1991
The dihydropyridine binding site of the rabbit skeletal muscle calcium channel alpha 1 subunit was identified using tritiated… Expand
Highly Cited
1991
Highly Cited
1991
Resistance of human cancer cells to multiple cytotoxic hydrophobic agents (multidrug resistance) is due to overexpression of the… Expand
Highly Cited
1989
Highly Cited
1989
Cells that express P-glycoprotein are resistant to many unrelated anticancer drugs. All evidence suggests that P-glycoprotein is… Expand
Highly Cited
1988
Highly Cited
1988
  • A. Safa
  • Proceedings of the National Academy of Sciences…
  • 1988
  • Corpus ID: 46234938
Verapamil, a phenylalkylamine calcium channel blocker, has been shown to reverse multidrug resistance in tumor cells, possibly by… Expand
Highly Cited
1987
Highly Cited
1987
A radioactive photoactive dihydropyridine calcium channel blocker, [3H]azidopine, was used to photoaffinity label plasma… Expand