• Publications
  • Influence
Antitumor Activity of Oenothein B, a Unique Macrocyclic Ellagitannin
TLDR
Results suggest that oenothein B exerts its antitumor effect through potentiation of the host‐immune defense via activation of macrophages.
Mitogen- and Stress-activated Protein Kinase 1 Mediates Activation of Akt by Ultraviolet B Irradiation*
TLDR
Investigation of the mechanism by which UVB irradiation activates Akt in mouse epidermal JB6 cells suggested that UVB-induced Akt activation was mediated through Msk1, which is a downstream kinase of the Erk and p38 kinase signaling pathways.
Anti-human immunodeficiency virus phenolics from licorice.
TLDR
Five phenolics isolated from licorice inhibited the cytopathic activity of a human immmunodeficiency virus and one of these, a coumarin derivative named licopyranocoumarin, had structure 5, based on the chemical and spectroscopic evidence.
Inhibition of Ultraviolet B–Induced AP‐1 Activation by Theaflavins From Black Tea
TLDR
It is found that theaflavins significantly inhibited activation of extracellular signal‐regulated protein kinases and c‐jun NH2‐terminal kinases, which may further explain the anti–tumor promotion action of these tea constituents.
Antitumor activities of ellagitannins against sarcoma-180 in mice.
TLDR
It is suggested that tannins need the ellagitannin monomer units, having galloyl groups at the O-2 and O-3 positions on the glucose core(s), such as tellimagrandins, in order to exhibit a strong antitumor activity.
Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester
TLDR
It is found that CAPE suppressed 12‐O‐tetradecanoylphorbol‐13‐acetate–induced cell transformation and induced apoptosis in mouse epidermal JB6 Cl 41 cells and this results suggested that p53 may be involved in the early stage of CAPE‐induced apoptosis.
Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastgenesis and osteoclastgenesis in culture and its therapeutic effects in rat osteopenia models.
TLDR
Results indicate that XT-44 could be a candidate as a therapeutic drug for treating osteopenia including osteoporosis, as well as in cell cultures and animal experiments.
Relationship between the structures and the antitumor activities of tannins.
TLDR
It seems to be essential for marked antitumor activity that ellagitannins should possess a dimeric structure with several galloyl groups on the glucose core.
Antitumor activity and interleukin-1 induction by tannins.
TLDR
It is indicated that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1 beta.
Effects of alkyl substitutions of xanthine skeleton on bronchodilation.
TLDR
Among these xanthine derivatives, 1-butyl-3-propylxanthine and its 7-methylated derivative showed high bronchoselectivity in the in vitro and in vivo experiments compared to theophylline and enprofylline and may be new candidates for bronchodilator.
...
1
2
3
4
5
...