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azatoxin

Known as: 1H,6H-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole 
 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Many lignans and neolignans have served as lead compounds for the development of new drugs. Perhaps the best known example is… Expand
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Highly Cited
2001
Highly Cited
2001
The synthesis and biological activity of amino acid functionalized beta-carboline derivatives, which are structurally related to… Expand
1999
1999
The DNA sequence selectivity of topoisomerase II (top2)-DNA cleavage complexes was examined for the human (top2α), yeast, and… Expand
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1997
1997
Eighteen analogues of the nonintercalative DNA topoisomerase II (topo II)-active epipodophyllotoxin-ellipticine hybrid, azatoxin… Expand
1997
1997
One approach to broadening the diversity of topoisomerase II-targeted anticancer agents is to generate novel compounds by… Expand
1995
1995
Azatoxin was rationally designed as a DNA topoisomerase II (top2) inhibitor [Leteurtre et al., Cancer Res 52: 4478-4483, 1992… Expand
Highly Cited
1994
Highly Cited
1994
BACKGROUND The cumulative cardiotoxicity of anthracyclines is thought to result from the generation of free radicals. New DNA… Expand
Highly Cited
1994
Highly Cited
1994
DNA methylation is deregulated during oncogenesis. Since several major anti-cancer drugs act on topoisomerases, we investigated… Expand
1993
1993
Azatoxin (NSC 640737) is a synthetic molecule that was rationally designed as a topoisomerase II inhibitor (Leteurtre et al… Expand
Highly Cited
1992
Highly Cited
1992
Azatoxin [NSC 640737-M; 5.R,11aS-1H,6H,3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydr oxyphenyl) oxazolo (3',4':1,6)pyrido… Expand
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