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azatoxin

Known as: 1H,6H-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole 
 
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
Many lignans and neolignans have served as lead compounds for the development of new drugs. Perhaps the best known example is… Expand
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2004
2004
Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are highly… Expand
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2001
2001
The synthesis and biological activity of amino acid functionalized beta-carboline derivatives, which are structurally related to… Expand
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1999
1999
The DNA sequence selectivity of topoisomerase II (top2)-DNA cleavage complexes was examined for the human (top2α), yeast, and… Expand
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1997
1997
One approach to broadening the diversity of topoisomerase II-targeted anticancer agents is to generate novel compounds by… Expand
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1995
1995
Azatoxin was rationally designed as a DNA topoisomerase II (top2) inhibitor [Leteurtre et al., Cancer Res 52: 4478-4483, 1992… Expand
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1994
1994
DNA methylation is deregulated during oncogenesis. Since several major anti-cancer drugs act on topoisomerases, we investigated… Expand
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1994
1994
BACKGROUND The cumulative cardiotoxicity of anthracyclines is thought to result from the generation of free radicals. New DNA… Expand
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1993
1993
Azatoxin (NSC 640737) is a synthetic molecule that was rationally designed as a topoisomerase II inhibitor (Leteurtre et al… Expand
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1992
1992
Azatoxin [NSC 640737-M; 5.R,11aS-1H,6H,3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydr oxyphenyl) oxazolo (3',4':1,6)pyrido… Expand
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