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azatoxin
Known as:
1H,6H-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (2)
Indoles
Topoisomerase II Inhibitors
Narrower (2)
NSC 640737
NSC 640737-M
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
New somatostatin-drug conjugates for effective targeting pancreatic cancer.
E. Ragozin
,
A. Hesin
,
+11 authors
G. Gellerman
Bioorganic & Medicinal Chemistry
2018
Corpus ID: 51677324
Review
2005
Review
2005
Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.
Youngjae You
Current pharmaceutical design
2005
Corpus ID: 24801613
Podophyllotoxin is an antimitotic natural product. Its inhibitory activity on cell growth led to the development of the…
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Highly Cited
2004
Highly Cited
2004
Lignans and neolignans as lead compounds
S. Apers
,
A. Vlietinck
,
L. Pieters
Phytochemistry Reviews
2004
Corpus ID: 7471820
Many lignans and neolignans have served as lead compounds for the development of new drugs. Perhaps the best known example is…
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2004
2004
A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II
Thomas Gruger
,
J. Nitiss
,
+5 authors
D. Strumberg
Antimicrobial Agents and Chemotherapy
2004
Corpus ID: 17766805
ABSTRACT Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are…
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Highly Cited
2001
Highly Cited
2001
The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors.
A. M. Deveau
,
M. Labroli
,
C. Dieckhaus
,
M. T. Barthen
,
K. Smith
,
T. Macdonald
Bioorganic & Medicinal Chemistry Letters
2001
Corpus ID: 42552305
1999
1999
Molecular Analysis of Yeast and Human Type II Topoisomerases
D. Strumberg
,
J. Nitiss
,
Jiaowang Dong
,
K. Kohn
,
Y. Pommier
Journal of Biological Chemistry
1999
Corpus ID: 24868297
The DNA sequence selectivity of topoisomerase II (top2)-DNA cleavage complexes was examined for the human (top2α), yeast, and…
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1997
1997
Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine.
S. D. Cline
,
T. Macdonald
,
N. Osheroff
Biochemistry
1997
Corpus ID: 29140893
One approach to broadening the diversity of topoisomerase II-targeted anticancer agents is to generate novel compounds by…
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Highly Cited
1994
Highly Cited
1994
Effects of DNA methylation on topoisomerase I and II cleavage activities.
F. Leteurtre
,
G. Kohlhagen
,
M. Fesen
,
A. Tanizawa
,
K. Kohn
,
Y. Pommier
Journal of Biological Chemistry
1994
Corpus ID: 7463155
Highly Cited
1994
Highly Cited
1994
Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen.
F. Leteurtre
,
G. Kohlhagen
,
K. Paull
,
Y. Pommier
Journal of the National Cancer Institute
1994
Corpus ID: 23975117
BACKGROUND The cumulative cardiotoxicity of anthracyclines is thought to result from the generation of free radicals. New DNA…
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Highly Cited
1992
Highly Cited
1992
Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.
F. Leteurtre
,
J. Madalengoitia
,
+4 authors
Y. Pommier
Cancer Research
1992
Corpus ID: 1798175
Azatoxin [NSC 640737-M; 5.R,11aS-1H,6H,3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydr oxyphenyl) oxazolo (3',4':1,6)pyrido…
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