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azatoxin

Known as: 1H,6H-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

IndolesTopoisomerase II Inhibitors

Narrower (2)

NSC 640737NSC 640737-M

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Rational Design and Molecular Effects of a New Topoisomerase II Inhibitor , Azatoxin 1
Azatoxin [NSC 640737-M; 5.R, 11aS-lH,6H,3-one-5,4,11,11 a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl) oxazolo (3',4':l,6)pyrido… 
Highly Cited
2001
Highly Cited
2001
The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors.
2001
2001
Synthesis of Imidazo[4,5‐d]oxazolo[3,4‐a]pyridines. New Heterocyclic Analogues of Lignans
The preparation of new analogues of lignans carrying an imidazole ring has been achieved. Starting from L‐histidinol, cis and… 
1999
1999
Differential in vitro interactions of a series of clinically useful topoisomerase-interacting compounds with the cleavage/religation activity of the human topoisomerase IIalpha and IIbeta isoforms.
The topoisomerase II (TOP2)-associated DNA cleavage activity and the DNA sequence preference of 20 antitumor drugs, including 15… 
1997
1997
Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues.
1995
1995
Cellular pharmacology of azatoxins (topoisomerase‐II and tubulin inhibitors) in P‐glycoprotein‐positive and ‐negative cell lines
Azatoxin (NSC 640737), a synthetic molecule, was rationally designed as a topoisomerase‐ll inhibitor and was shown to be a potent… 
1994
1994
Effects of DNA methylation on topoisomerase I and II cleavage activities.
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