M. Medarde

Publications190
h-index27
Citations2,358
Highly Influential Citations37
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A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
Concepcion P. Melero*, Manuel Medarde and Arturo San FelicianoDepartamento de Quimica Farmaceutica, Facultad de Farmacia, Campus Miguel de Unamuno, 37007Salamanca, SpainTel.: +34 923 29 45 28, Fax:… Expand
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Biosynthesis of podophyllotoxin in Linum album cell cultures
Abstract. Cell cultures of Linum album Kotschy ex Boiss. (Linaceae) showing high accumulation of the lignan podophyllotoxin (PTOX) were established. Enzymological studies revealed highest activities… Expand
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Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
By synthesis and biological studies of new naphthalene analogues of combretastatins, we have found that the naphthalene is a good surrogate for the isovanillin moiety (3-hydroxy-4-methoxyphenyl) of… Expand
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Synthesis and characterization of the new cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate.
Owing to the high efficiency of hepatocytes to take up bile acids, these endogenous compounds or their analogues can be considered as potential shuttles for delivering drugs to the liver. With the… Expand
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Plant cell factories as a source for anti-cancer lignans
The review places podophyllotoxin, a powerful anti-cancer material used in clinical treatment of small cell cancers, in focus. The economical synthesis of podophyllotoxin is not feasible and demand… Expand
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Anti-HIV activity of some synthetic lignanolides and intermediates.
The evaluation of the anti-HIV-1 activity of synthetic lignanolides and their intermediates is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1… Expand
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Synthesis and Biological Activity of Bromolignans and Cyclolignans
Nine lignan derivatives (4‐12) have been obtained from (‐)‐yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P‐388, A‐549, HT‐29) compared with podophyllotoxin, but… Expand
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Kudtdiol, new sesquiterpene alcohol from D.C.
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A new family of quinoline and quinoxaline analogues of combretastatins.
The 3-hydroxy-4-methoxyphenyl ring of combretastatin A-4 can be replaced by a 2-naphthyl moiety without significant loss of cytotoxicity and inhibition of tubulin polymerization potency. In this… Expand
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Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.
Isocombretastatins A are 1,1-diarylethene isomers of combretastatins A. We have synthesized the isomers of combretastatin A-4, deoxycombretastatin A-4, 3-amino-deoxycombretastatin A-4 (AVE-8063),… Expand
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