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aptamer

Known as: aptamers 
Double-stranded DNA or single-stranded RNA oligonucleotide sequences with the capacity to recognize target molecules with high affinity and… 
National Institutes of Health

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Related topics

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Oligonucleotides

Papers overview

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Highly Cited
2010
Highly Cited
2010
A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer.
Computed tomography (CT) is one of the most useful diagnostic tools among commonly used biomedical imaging techniques, which also… 
Highly Cited
2010
Highly Cited
2010
Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach.
Molecular medicine is an emerging field focused on understanding the molecular basis of diseases and translating this information… 
Highly Cited
2010
Highly Cited
2010
Label-free biosensors based on aptamer-modified graphene field-effect transistors.
A label-free immunosensor based on an aptamer-modified graphene field-effect transistor (G-FET) is demonstrated. Immunoglobulin E… 
Highly Cited
2009
Highly Cited
2009
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been targeted with RNA aptamer–small interfering… 
Highly Cited
2006
Highly Cited
2006
An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform.
The active targeting of drugs in a cell-, tissue-, or diseasespecific manner represents a potentially powerful technology with… 
Highly Cited
2006
Highly Cited
2006
Aptamer mediated siRNA delivery
Nucleic acids that bind to cells and are subsequently internalized could prove to be novel delivery reagents. An anti-prostate… 
Highly Cited
2003
Highly Cited
2003
A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment
The targeting of molecular repertoires to complex systems rather than biochemically pure entities is an accessible approach that… 
Highly Cited
2003
Highly Cited
2003
Aptamers switch on fluorescence of triphenylmethane dyes.
MG and SRB aptamers, which are short RNA sequences originally selected only for binding to malachite green or sulforhodamine B… 
Highly Cited
2000
Highly Cited
2000
Fluorescent Sensors Based on Aptamer Self-Assembly.
In vitro selection of oligonucleotides has made possible the isolation of aptamers with high binding affinity for small molecules… 
Highly Cited
1998
Highly Cited
1998
DNA-enhanced peroxidase activity of a DNA-aptamer-hemin complex.
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