GnRH binding RNA and DNA Spiegelmers: a novel approach toward GnRH antagonism.

  title={GnRH binding RNA and DNA Spiegelmers: a novel approach toward GnRH antagonism.},
  author={Susanne Leva and Andrea Lichte and J. Burmeister and Peter Muhn and Birgit Jahnke and Dirk Fesser and Jeannette Erfurth and Petra Burgstaller and Sven Klu\ssmann},
  journal={Chemistry & biology},
  volume={9 3},
Mirror-image oligonucleotide ligands (Spiegelmers) that bind to the pharmacologically relevant target gonadotropin-releasing hormone I (GnRH) with high affinity and high specificity have been identified using the Spiegelmer technology. GnRH is a decapeptide that plays an important role in mammalian reproduction and sexual maturation and is associated with several benign and malignant diseases. First, aptamers that bind to D-GnRH with dissociation constants of 50-100 nM were isolated out of RNA… CONTINUE READING


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