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apicidin

Known as: cyclo(N-O-methyl-tryptophyl-isoleucyl-pipecolinyl-2-amino-8-oxodecanoyl) 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclic PeptidesHistone deacetylase inhibitor

Narrower (1)

apicidin C

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells.
BACKGROUND Apicidin, as an inhibitor of histone deacetylase, showed a wide range of antiproliferative activity against various… 
2010
2010
Apicidin upregulates PHD2 prolyl hydroxylase gene expression in cervical cancer cells
It was recently reported that the reduced expression of hypoxia-inducible factor prolyl 4-hydroxylase PHD2 in human cancers… 
2009
2009
Systemic cell-cycle suppression by Apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells.
Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents for the treatment of… 
2008
2008
Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells.
The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression of… 
2007
2007
Relationship between embryonic histonic hyperacetylation and axial skeletal defects in mouse exposed to the three HDAC inhibitors apicidin, MS-275, and sodium butyrate.
Some histone deacetylase inhibitors (HDACi) have recently been related to teratogenic effects in rodents. Skeletal defects have… 
2007
2007
Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors.
2006
2006
Activation of NF-κB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis
Histone deacetylase (HDAC) inhibitors are promising anti-cancer drugs, but these exert differential responses depending on the… 
2005
2005
Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a…
Apicidin, a fungal metabolite isolated from Fusarium pallidoroseum, is a cyclic tetrapeptide that exhibits potent anti-protozoal… 
2004
2004
Apicidin potentiates the imatinib‐induced apoptosis of Bcr–Abl‐positive human leukaemia cells by enhancing the activation of mitochondria‐dependent caspase cascades
Apicidin, a histone deacetylase inhibitor, is a novel cyclic tetrapeptide with potent antiproliferative activity against various… 
Highly Cited
2000
Highly Cited
2000
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Apicidin's indole was efficiently converted into a series of N-substituted quinolone derivatives by indole N-alkylation followed… 
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