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apicidin

Known as: cyclo(N-O-methyl-tryptophyl-isoleucyl-pipecolinyl-2-amino-8-oxodecanoyl) 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclic PeptidesHistone deacetylase inhibitor

Narrower (1)

apicidin C

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a key role in the control of gene… Expand
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Highly Cited
2008
Highly Cited
2008
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure.
AIMS Recent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the… Expand
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Highly Cited
2004
Highly Cited
2004
Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.
Apicidin has been identified as a histone deacetylase (HDAC) inhibitor. Since HDAC inhibitors are emerging as an exciting new… Expand
Highly Cited
2003
Highly Cited
2003
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1…
Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in human leukemia and lymphoma cells (U937, HL-60… Expand
Highly Cited
2003
Highly Cited
2003
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.
Pharmacologic stimulation of fetal hemoglobin (HbF) expression may be a promising approach for the treatment of beta-thalassemia… Expand
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Highly Cited
2002
Highly Cited
2002
Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells*
We previously reported that apicidin arrested human cancer cell growth through selective induction of p21WAF1/Cip1. In this study… Expand
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2001
2001
Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions.
[structure: see text]. Isolation and structure elucidation of two novel cyclic tetrapeptides that show a variety of potent… Expand
Highly Cited
2000
Highly Cited
2000
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
Apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amino-8-oxodecanoyl)] is a fungal metabolite shown to… Expand
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Highly Cited
2000
Highly Cited
2000
Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype.
Cancer metastasis represents the most important cause of cancer death and agents that may inhibit tumor cell invasion have been… Expand
Highly Cited
1996
Highly Cited
1996
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
A novel fungal metabolite, apicidin [cyclo(N-O-methyl-L-tryptophanyl-L -isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], that… Expand
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