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apicidin

Known as: cyclo(N-O-methyl-tryptophyl-isoleucyl-pipecolinyl-2-amino-8-oxodecanoyl) 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclic PeptidesHistone deacetylase inhibitor

Narrower (1)

apicidin C

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Replication Efficiency of Soil-Bound Prions Varies with Soil Type
ABSTRACT Prion sorption to soil is thought to play an important role in the transmission of scrapie and chronic wasting disease… Expand
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Highly Cited
2008
Highly Cited
2008
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure.
AIMS Recent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the… Expand
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Highly Cited
2008
Highly Cited
2008
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a key role in the control of gene… Expand
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2008
2008
Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells.
The histone deacetylase (HDAC) inhibitor, apicidin, has been shown to suppress the growth of human breast cancer cells. In this… Expand
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Highly Cited
2004
Highly Cited
2004
Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.
Apicidin has been identified as a histone deacetylase (HDAC) inhibitor. Since HDAC inhibitors are emerging as an exciting new… Expand
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Highly Cited
2003
Highly Cited
2003
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1…
Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in human leukemia and lymphoma cells (U937, HL-60… Expand
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Highly Cited
2003
Highly Cited
2003
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.
Pharmacologic stimulation of fetal hemoglobin (HbF) expression may be a promising approach for the treatment of beta-thalassemia… Expand
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Highly Cited
2002
Highly Cited
2002
Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells*
We previously reported that apicidin arrested human cancer cell growth through selective induction of p21WAF1/Cip1. In this study… Expand
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Highly Cited
2000
Highly Cited
2000
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
Apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amino-8-oxodecanoyl)] is a fungal metabolite shown to… Expand
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Highly Cited
1996
Highly Cited
1996
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
A novel fungal metabolite, apicidin [cyclo(N-O-methyl-L-tryptophanyl-L -isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], that… Expand
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