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apicidin
Known as:
cyclo(N-O-methyl-tryptophyl-isoleucyl-pipecolinyl-2-amino-8-oxodecanoyl)
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Cyclic Peptides
Histone deacetylase inhibitor
Narrower (1)
apicidin C
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells.
Jianye Zhang
,
Zhen‐zhen Lai
,
+5 authors
Yiwen Tao
Anti-Cancer Agents in Medicinal Chemistry
2017
Corpus ID: 23464548
BACKGROUND Apicidin, as an inhibitor of histone deacetylase, showed a wide range of antiproliferative activity against various…
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2010
2010
Apicidin upregulates PHD2 prolyl hydroxylase gene expression in cervical cancer cells
Marta Durczak
,
P. Jagodziński
Anti-Cancer Drugs
2010
Corpus ID: 8650344
It was recently reported that the reduced expression of hypoxia-inducible factor prolyl 4-hydroxylase PHD2 in human cancers…
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2009
2009
Systemic cell-cycle suppression by Apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells.
J. Noh
,
Jae Hwi Song
,
+10 authors
S. Nam
International Journal of Molecular Medicine
2009
Corpus ID: 20303612
Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents for the treatment of…
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2008
2008
Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells.
Hyeyoung Park
,
J. Im
,
Jeonga Kim
,
W. Choi
,
Hyung Sik Kim
International Journal of Molecular Medicine
2008
Corpus ID: 2910231
The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression of…
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2007
2007
Relationship between embryonic histonic hyperacetylation and axial skeletal defects in mouse exposed to the three HDAC inhibitors apicidin, MS-275, and sodium butyrate.
F. Di Renzo
,
M. L. Broccia
,
E. Giavini
,
E. Menegola
Toxicological Sciences
2007
Corpus ID: 12089030
Some histone deacetylase inhibitors (HDACi) have recently been related to teratogenic effects in rodents. Skeletal defects have…
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2007
2007
Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors.
K. Ishihara
,
Aki Takahashi
,
+5 authors
K. Ohuchi
Life Science
2007
Corpus ID: 46284346
2006
2006
Activation of NF-κB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis
Y. K. Kim
,
E. Lee
,
+9 authors
J-W Han
Cell Death and Differentiation
2006
Corpus ID: 8810143
Histone deacetylase (HDAC) inhibitors are promising anti-cancer drugs, but these exert differential responses depending on the…
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2005
2005
Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a…
B. Shin
,
John Kim
,
+4 authors
S. Yoo
Rapid Communications in Mass Spectrometry
2005
Corpus ID: 26574521
Apicidin, a fungal metabolite isolated from Fusarium pallidoroseum, is a cyclic tetrapeptide that exhibits potent anti-protozoal…
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2004
2004
Apicidin potentiates the imatinib‐induced apoptosis of Bcr–Abl‐positive human leukaemia cells by enhancing the activation of mitochondria‐dependent caspase cascades
Jin Seok Kim
,
Hoi-kyung Jeung
,
+5 authors
Y. Min
British Journal of Haematology
2004
Corpus ID: 24697860
Apicidin, a histone deacetylase inhibitor, is a novel cyclic tetrapeptide with potent antiproliferative activity against various…
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Highly Cited
2000
Highly Cited
2000
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
P. Meinke
,
S. Colletti
,
+9 authors
M. Fisher
Journal of Medicinal Chemistry
2000
Corpus ID: 10437625
Apicidin's indole was efficiently converted into a series of N-substituted quinolone derivatives by indole N-alkylation followed…
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