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apicidin

Known as: cyclo(N-O-methyl-tryptophyl-isoleucyl-pipecolinyl-2-amino-8-oxodecanoyl) 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclic PeptidesHistone deacetylase inhibitor

Narrower (1)

apicidin C

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells.
BACKGROUND Apicidin, as an inhibitor of histone deacetylase, showed a wide range of antiproliferative activity against various… 
2013
2013
Apicidin-Resistant HA22T Hepatocellular Carcinoma Cells strongly activated the Wnt/β-Catenin Signaling Pathway and MMP-2 Expression via the IGF-IR/PI3K/Akt Signaling Pathway Enhancing Cell Metastatic…
The IGF-IR/PI3K/Akt signaling pathway inhibited GSK3-β activity by phosphorylation and this promoted β-catenin nuclear… 
2010
2010
Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
BackgroundGranulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution… 
Highly Cited
2009
Highly Cited
2009
Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.
Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were… 
2008
2008
Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells.
The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression of… 
2007
2007
Relationship between embryonic histonic hyperacetylation and axial skeletal defects in mouse exposed to the three HDAC inhibitors apicidin, MS-275, and sodium butyrate.
Some histone deacetylase inhibitors (HDACi) have recently been related to teratogenic effects in rodents. Skeletal defects have… 
2006
2006
Activation of NF-κB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis
Histone deacetylase (HDAC) inhibitors are promising anti-cancer drugs, but these exert differential responses depending on the… 
2004
2004
Apicidin potentiates the imatinib‐induced apoptosis of Bcr–Abl‐positive human leukaemia cells by enhancing the activation of mitochondria‐dependent caspase cascades
Apicidin, a histone deacetylase inhibitor, is a novel cyclic tetrapeptide with potent antiproliferative activity against various… 
2003
2003
Expression of p21WAF1/Cip1 through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase–PKCε signaling pathway
We previously reported that the activation of p21WAF1/Cip1 transcription by histone deacetylase inhibitor apicidin was mediated… 
Highly Cited
2000
Highly Cited
2000
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Apicidin's indole was efficiently converted into a series of N-substituted quinolone derivatives by indole N-alkylation followed… 
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