Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells.

@article{Park2008EffectsOA,
  title={Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells.},
  author={Hyeyoung Park and Ji Young Im and Jeonga Kim and Wahn Soo Choi and Hyung Sik Kim},
  journal={International journal of molecular medicine},
  year={2008},
  volume={21 3},
  pages={325-33}
}
The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression of oncogenic Ras. However, the ability of HDAC inhibitors to regulate the apoptotic pathway in human breast cancer cells is still not completely understood. In this study, the anti-proliferative effects of apicidin were compared in H-ras-transformed human breast epithelial (MCF10A-ras) and non-transformed epithelial (MCF10A) cells. MCF10A-ras cells showed a significantly… CONTINUE READING