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Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus*
It is suggested that curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair is suggested.
Effects of Gestational Exposure to Decabromodiphenyl Ether on Reproductive Parameters, Thyroid Hormone Levels, and Neuronal Development in Sprague-Dawley Rats Offspring
There was no apparent association between thyroid hormone concentrations and low birth weight in F1 rats after gestational exposure to BDE-209, and there was no significant effect on hippocampal neurogenesis in BME treatment groups.
  • B. Shin, C. Kim, S. Yoo
  • Biology, Chemistry
    Journal of toxicology and environmental health…
  • 1 December 2004
A physiologically based pharmacokinetic (PBPK) model consisting of vein, artery, lung, liver, spleen, kidneys, heart, testes, muscle, brain, adipose tissue, stomach, and small intestine was developed
Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein
This work investigated whether Sal could sensitize cancer cells to the effects of doxorubicin (DOX) or etoposide (ETO) and found that it did so.
Estrogenic Endocrine-Disrupting Chemicals: Molecular Mechanisms of Actions on Putative Human Diseases
A review of the adverse effects of estrogenic EDC on male or female reproductive systems and molecular mechanisms underlying EDC effects that modulate ER-mediated signaling finds mechanisms of action may involve both ER-dependent and ER-independent pathways.
The data suggest that DBP is likely to exert its antiandrogenic actions through disruption of AR or ERβ expression during the early neonatal stage, and that neonatal exposure to DBP produces permanent changes in the endocrine system and leads to abnormal male reproductive-tract development until puberty.
Risk Assessment of Volatile Organic Compounds Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) in Consumer Products
Exposure and risk assessment was performed by evaluating levels of volatile organic compounds (VOC) benzene, toluene, ethylbenzene, and xylene in 207 consumer products, suggesting that exposure to VOC via some consumer products exceeded the safe limits and needs to be reduced.
Suppressive Effects of Bisphenol A on the Proliferation of Neural Progenitor Cells
The data show adverse effects of BPA on the nervous system and potentially on neonatal brain development, as well as oxidative stress-related cytotoxicity, in murine-derived multipotent neural progenitor cells.
Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide.
The data demonstrate that the rodent pubertal female assay is useful for identifying potential EDs having not only estrogenic/antiestrogenic but also androgenic/antiandrogenic activities, however, further validation study is necessary to identify chemicals that operate through other action mechanisms, including steroid biosynthesis inhibitors and thyroid inhibitors.
Risk Assessment of Bisphenol a Migrated from Canned Foods in Korea
Evidence indicates that the levels of BPA levels in canned foods are not likely to constitute a safety concern for consumers in Korea, and the potential risk for BPA contamination due to consumption of each canned food items was calculated to be 0.03.