anti-CD137 monoclonal antibody

Known as: Anti-4-1BB Monoclonal Antibody, Immunoglobulin G4, Anti-(Human Receptor 4-1BB) (Human Gamma-Chain), Disulfide with Human Kappa-Chain, Dimer, Urelumab 
A fully human agonistic monoclonal antibody targeting the CD137 receptor with potential immunostimulatory and antineoplastic activities. Anti-CD137… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
012319992017

Papers overview

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2017
2017
Purpose: Urelumab is an agonist antibody to CD137 with potential application as an immuno-oncology therapeutic. Data were… (More)
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2017
2017
PURPOSE Cetuximab, an EGFR-specific antibody (mAb), modestly improves clinical outcome in patients with head and neck cancer (HNC… (More)
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2017
2017
Triple-negative breast cancer (TNBC) highly infiltrated with CD8+ tumor-infiltrating lymphocytes (TIL) has been associated with… (More)
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2015
2015
A current pressing need in cancer immunology is the development of preclinical model systems that are immunocompetent for the… (More)
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2015
2015
CD137 (4-1BB) is a surface protein initially discovered to mark activated T lymphocytes. However, its broader expression pattern… (More)
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Highly Cited
2013
Highly Cited
2013
Modulation of the immune system by targeting coinhibitory and costimulatory receptors has become a promising new approach of… (More)
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2013
2013
Recent investigations of the tumor microenvironment have shown that many tumors are infiltrated by inflammatory and lymphocytic… (More)
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2009
2009
Chemotherapy can precondition for immunotherapy by creating an environment for homeostatic lymphoproliferation and eliminating… (More)
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2004
2004
Bacterial infection sometimes impairs bone metabolism. In this study, we infected the osteoblastic cell line MC3T3-E1 with… (More)
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Highly Cited
1999
Highly Cited
1999
The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the… (More)
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