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ansamitocins

National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

MaytansineTubulin Modulators
analogs & derivatives

Narrower (1)

ansamitocin P 3

Papers overview

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2013
2013
Effects Analysis of Adding Branched Amino Acids on the Biosynthesis of Ansamitocins by Actinosynnema mirum
Ansamitocins are a group of macrolide antibiotics,which include five components,i.e., AP-1,AP-2,AP-3,AP-3′and AP-4.Among these… 
2012
2012
The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.
The broad use of natural products in the development of new drugs is currently hampered by the fact that they are too complex and… 
2012
2012
Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.
Access of four new tumor specific folic acid/ansamitocin conjugates is reported that relies on a synthetic strategy based on the… 
1984
1984
Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones.
As part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we… 
1984
1984
Chemical modification of ansamitocins. III. Synthesis and biological effects of 3-acyl esters of maytansinol.
Several semisynthetic maytansinoids that differ in the structure of the acyl group at the C3 position were prepared by acylation… 
1981
1981
Demethylation of ansamitocins and related compounds.
Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from… 
1981
1981
Ansamitocin analogs from a mutant strain of Nocardia. I. Isolation of the mutant, fermentation and antimicrobial properties.
A mutant having a high ability to produce ansamitocins was derived from a dnacin-producing strain, Nocardia sp. No. C-14482 (N… 
1980
1980
Ansamitocins, maytansinoid antitumor antibiotics. Producing organism, fermentation, and antimicrobial activities.
The general pharmacology of aclacinomycin A, a new antitumor antibiotic, was studied in mice, rats, guinea-pigs, frogs, rabbits… 
1980
1980
Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro.
Abstract The antitumor and antitubulin activities of newly isolated antibiotics, ansamitocin P-3 (P-3) and ansamitocin P-4 (P-4… 
1979
1979
Inhibition ofCilia Regeneration ofTetrahymena by Ansamitocins, NewAntitumor Antibiotics
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