ansamitocins
National Institutes of Health
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Ansamitocins are a group of macrolide antibiotics,which include five components,i.e., AP-1,AP-2,AP-3,AP-3′and AP-4.Among these…
As part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we…
Several semisynthetic maytansinoids that differ in the structure of the acyl group at the C3 position were prepared by acylation…
Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from…
A mutant having a high ability to produce ansamitocins was derived from a dnacin-producing strain, Nocardia sp. No. C-14482 (N…
The general pharmacology of aclacinomycin A, a new antitumor antibiotic, was studied in mice, rats, guinea-pigs, frogs, rabbits…
Abstract The antitumor and antitubulin activities of newly isolated antibiotics, ansamitocin P-3 (P-3) and ansamitocin P-4 (P-4…
Ansamitocins inhibited cell division in Tetrahymena pyriformis W at low concentrations and caused cells to become more rounded…
Ansamitocins inhibited cilia regeneration of partially deciliated Tetrahymena pyriformis W, and the activity depended on the acyl…