ansamitocins
National Institutes of Health
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Ansamitocins are a group of macrolide antibiotics,which include five components,i.e., AP-1,AP-2,AP-3,AP-3′and AP-4.Among these…
The broad use of natural products in the development of new drugs is currently hampered by the fact that they are too complex and…
Access of four new tumor specific folic acid/ansamitocin conjugates is reported that relies on a synthetic strategy based on the…
As part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we…
Several semisynthetic maytansinoids that differ in the structure of the acyl group at the C3 position were prepared by acylation…
Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from…
A mutant having a high ability to produce ansamitocins was derived from a dnacin-producing strain, Nocardia sp. No. C-14482 (N…
The general pharmacology of aclacinomycin A, a new antitumor antibiotic, was studied in mice, rats, guinea-pigs, frogs, rabbits…
Abstract The antitumor and antitubulin activities of newly isolated antibiotics, ansamitocin P-3 (P-3) and ansamitocin P-4 (P-4…