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ansamitocin P 3

Known as: Ansamitomicin P-3, Maytansine, 3-o-de(2-(acetylmethylamino)-1-oxopropyl)-3-o-(1-oxobutyl)- 
An ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P… 
National Institutes of Health

Papers overview

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2018
2018
Ansamitocin P‐3 (AP‐3) produced by Actinosynnema pretiosum is an important antitumor agent for cancer treatment, but its market… 
2013
2013
Ansamitocin P-3 (AP-3), a secondary metabolite produced by Actinosynnema pretiosum, is well known for its extraordinary antitumor… 
2007
2007
[reaction: see text] The enantioselective total synthesis of proansamitocin, a key biosynthetic intermediate of the highly potent… 
2006
2006
Ansamitocin P-3 is a potent antitumor agent produced by A. pretiosum. A deletion mutant of A. pretiosum was constructed by… 
2005
2005
Maytansine, a potent clinically evaluated plant-derived anti-tumor drug, and its microbial counterpart, ansamitocin P-3, showed a… 
2005
2005
The Plackett-Burman design and the response surface method (RSM) with a central composite design (CCD) were employed to develop a… 
1984
1984
As part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we… 
1982
1982
Recently, GHISALBA et al.2,3) showed that the aminobenzenoid nucleus of rifamycin produced by Nocardia mediterranei was derived… 
1981
1981
Ansamitocin P-3 was converted into 15-hydroxyansamitocin P-3 (PHO-3), C32H43ClN2010, and 15-epi-15-hydroxyansamitocin P-3 (epi… 
1981
1981
Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from…