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ansamitocin P 3

Known as: Ansamitomicin P-3, Maytansine, 3-o-de(2-(acetylmethylamino)-1-oxopropyl)-3-o-(1-oxobutyl)- 
An ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P… 
National Institutes of Health

Related topics

Related topics

3 relations
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Broader (1)

ansamitocins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Metabolomic change and pathway profiling reveal enhanced ansamitocin P-3 production in Actinosynnema pretiosum with low organic nitrogen availability in culture medium
Ansamitocin P-3 (AP-3), a 19-membered polyketide macrocyclic lactam, has potent antitumor activity. Our previous study showed… 
2013
2013
Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose
Ansamitocin P-3 (AP-3), a secondary metabolite produced by Actinosynnema pretiosum, is well known for its extraordinary antitumor… 
2007
2007
Chemoenzymatic approaches toward dechloroansamitocin P-3.
[reaction: see text] The enantioselective total synthesis of proansamitocin, a key biosynthetic intermediate of the highly potent… 
2005
2005
Statistical Approach to Development of Culture Medium for Ansamitocin P-3 Production with Actinosynnema pretiosum ATCC 31565
The Plackett-Burman design and the response surface method (RSM) with a central composite design (CCD) were employed to develop a… 
2005
2005
Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry.
Maytansine, a potent clinically evaluated plant-derived anti-tumor drug, and its microbial counterpart, ansamitocin P-3, showed a… 
1985
1985
Reaction of DNA with a mutagenic 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido[1,2-a:3',2'- d]imidazole (N-AcO-AGlu-P-3) related to glutamic acid pyrolysates.
3-Amino-4,6-dimethyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-3), an analog amine of the potent genotoxic Glu-P-1 isolated from a… 
1984
1984
Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones.
As part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we… 
1982
1982
Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics.
Recently, GHISALBA et al.2,3) showed that the aminobenzenoid nucleus of rifamycin produced by Nocardia mediterranei was derived… 
1981
1981
Hydroxylation of ansamitocin P-3.
Ansamitocin P-3 was converted into 15-hydroxyansamitocin P-3 (PHO-3), C32H43ClN2010, and 15-epi-15-hydroxyansamitocin P-3 (epi… 
1981
1981
Demethylation of ansamitocins and related compounds.
Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from… 
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