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ansamitocin P 3

Known as: Ansamitomicin P-3, Maytansine, 3-o-de(2-(acetylmethylamino)-1-oxopropyl)-3-o-(1-oxobutyl)- 
An ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P… 
National Institutes of Health

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Related topics

3 relations
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Broader (1)

ansamitocins

Papers overview

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2013
2013
Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose
Ansamitocin P-3 (AP-3), a secondary metabolite produced by Actinosynnema pretiosum, is well known for its extraordinary antitumor… 
2010
2010
Preparative isolation and purification of anti-tumor agent ansamitocin P-3 from fermentation broth of Actinosynnema pretiosum using high-performance counter-current chromatography.
Ansamitocin P-3 is a potent anti-tumor maytansinoid found in Actinosynnema pretiosum. However, due to the complexity of the… 
2007
2007
Chemoenzymatic approaches toward dechloroansamitocin P-3.
[reaction: see text] The enantioselective total synthesis of proansamitocin, a key biosynthetic intermediate of the highly potent… 
2005
2005
Statistical Approach to Development of Culture Medium for Ansamitocin P-3 Production with Actinosynnema pretiosum ATCC 31565
The Plackett-Burman design and the response surface method (RSM) with a central composite design (CCD) were employed to develop a… 
2005
2005
Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry.
Maytansine, a potent clinically evaluated plant-derived anti-tumor drug, and its microbial counterpart, ansamitocin P-3, showed a… 
1985
1985
Reaction of DNA with a mutagenic 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido[1,2-a:3',2'- d]imidazole (N-AcO-AGlu-P-3) related to glutamic acid pyrolysates.
3-Amino-4,6-dimethyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-3), an analog amine of the potent genotoxic Glu-P-1 isolated from a… 
1984
1984
Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones.
As part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we… 
1982
1982
Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics.
Recently, GHISALBA et al.2,3) showed that the aminobenzenoid nucleus of rifamycin produced by Nocardia mediterranei was derived… 
1981
1981
Hydroxylation of ansamitocin P-3.
Ansamitocin P-3 was converted into 15-hydroxyansamitocin P-3 (PHO-3), C32H43ClN2010, and 15-epi-15-hydroxyansamitocin P-3 (epi… 
1981
1981
Demethylation of ansamitocins and related compounds.
Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from… 
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