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Macrophage activating effects of new alkamides from the roots of Echinacea species.
Data suggest that these alkamides may have anti-inflammatory activity, as they exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase.
- L. Paige, G. Q. Zheng, S. Defrees, J. Cassady, R. Geahlen
- Chemistry, BiologyBiochemistry
- 20 November 1990
Three myristic acid derivatives bearing different substituents at the 2-position were synthesized and shown to be competitive inhibitors of NMT in vitro, suggesting that the enhanced inhibitory potency of 2-hydroxymyristic Acid seen in cells was most probably a result of its metabolic activation to the CoA thioester.
Isolation of potential cancer chemopreventive agents from Eriodictyon californicum.
- Y. L. Liu, D. K. Ho, J. Cassady, V. Cook, W. Baird
- Chemistry, BiologyJournal of natural products
- 1 March 1992
Activity-based fractionation of Eriodictyon californicum resulted in the isolation of 12 flavonoids that inhibit the metabolism of the carcinogen benzo[a]pyrene by hamster embryo cells in tissue culture, indicating that these flavones warrant further investigation in vivo as potential chemopreventive agents.
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.
Bioassay-directed purification of the active compounds led to the isolation of the new compound corylifolin and the known compound bakuchiol as DNA polymerase inhibitors.
Reversible palmitoylation of the protein-tyrosine kinase p56lck.
Recent developments in the maytansinoid antitumor agents.
New developments in this field during the last two decades include the use of maytansinoids as "warheads" in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.
Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts.
The results suggest that the ability of black raspberries to inhibit tumor development may be mediated by impairing signal transduction pathways leading to activation of AP-1 and NFkappaB.
Potential cancer chemopreventive and cytotoxic agents from Pulicaria crispa.