Maytansine

Known as: alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione, L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)], Maysanine 
An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site… (More)
National Institutes of Health

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27 relations

Narrower (15)

AMG 595AVE9633IMGN853SAR 3419
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Broader (4)

Antibiotics, AntineoplasticAntineoplastic Agents, PhytogenicMacrolide AntibioticsTubulin Modulators
In BloodMicrotubule Processagonistsanalogs & derivatives
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Papers overview

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Review
2011
Review
2011
Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer.
Trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor (HER2)-targeted antibody-drug conjugate, composed of… (More)
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Highly Cited
2010
Highly Cited
2010
Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules.
Maytansine is a potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar… (More)
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Highly Cited
2010
Highly Cited
2010
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
Trastuzumab (Herceptin®) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab… (More)
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Review
2008
Review
2008
Targeted cancer therapy: conferring specificity to cytotoxic drugs.
The therapeutic activity of most anticancer drugs in clinical use is limited by their general toxicity to proliferating cells… (More)
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2006
2006
In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway.
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors and key regulators of lipid… (More)
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Review
2004
Review
2004
Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.
Since the milestone work of Evans and Scott, demonstrating the replication dependence of alkylation-induced aberrations, and Obe… (More)
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Highly Cited
1994
Highly Cited
1994
Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes.
The binding parameters of radiolabeled DAMGO (mu), DPDPE and pCl-DPDPE (delta) and 5 alpha, 7 alpha, 8 beta-N-methyl-N-[7-(1… (More)
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Review
1992
Review
1992
Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.
This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca… (More)
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1984
1984
Chemical synthesis and serology of disaccharides and trisaccharides of phenolic glycolipid antigens from the leprosy bacillus and preparation of a disaccharide protein conjugate for serodiagnosis of…
We examined the structural requirements within the species-specific 3,6-di-O-methyl-beta-D-glucopyranosyl-(1 leads to 4)-2,3-di-O… (More)
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Highly Cited
1975
Highly Cited
1975
Antimitotic activity of the potent tumor inhibitor maytansine.
Maytansine, at 6x10(-8)M, irreversibly inhibits cell division in eggs of sea urchins and clams. It causes the disappearance of a… (More)
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