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Maytansine

Known as: alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione, L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)], Maysanine 
An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (17)

AMG 595AVE9633IMGN853N-methylmaysenine

Broader (4)

Antibiotics, AntineoplasticAntineoplastic Agents, PhytogenicMacrolide AntibioticsTubulin Modulators
In BloodMicrotubule ProcessNCIt Antineoplastic Agent Terminologyagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia.
Highly Cited
2002
Highly Cited
2002
Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3…
Accelerator mass spectrometry (AMS) has been used in a human mass balance and metabolism study to analyze samples taken from four… 
Review
1989
Review
1989
Animal models of amyotrophic lateral sclerosis and the spinal muscular atrophies
Highly Cited
1981
Highly Cited
1981
Effects of inhibitors of tubulin polymerization on GTP hydrolysis.
Highly Cited
1981
Highly Cited
1981
Effects of motility inhibitors during sea urchin fertilization: microfilament inhibitors prevent sperm incorporation and restructuring of fertilized egg cortex, whereas microtubule inhibitors prevent…
Highly Cited
1978
Highly Cited
1978
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.
In vitro, deoxyuridine (dU) failed to block the incorporation of 3H-thymidine into bone marrow from 11 cases of vitamin B,2… 
Highly Cited
1972
Highly Cited
1972
Isolation of glycoproteins from pig lymphocyte plasma membrane using Lens culinaris phytohemagglutinin.
Highly Cited
1970
Highly Cited
1970
Reaction rates and biological action of N-methyl- and N-ethyl-N-nitrosourea.
Highly Cited
1968
Highly Cited
1968
Escherichia coli B N5-methyltetrahydrofolate-homocysteine vitamin-B12 transmethylase: formation and photolability of a methylcobalamin enzyme.
Highly Cited
1965
Highly Cited
1965
THE METABOLISM OF VOLATILE ANESTHETICS. II. IN VITRO METABOLISM OF METHOXYFLURANE AND HALOTHANE IN RAT LIVER SLICES AND CELL FRACTIONS.
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