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Biological and chemical monitoring of occupational exposure to ethylene oxide.
Studies were carried out on two populations occupationally exposed to ethylene oxide (EtO) using different physical and biological parameters. Blood samples were collected from 9 hospital workersExpand
Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide.
Abstract The degree of alkylation of proteins was used to determined tissue doses D t i.e. the concentration of free alkylating agent, integrated over time, in resting male mice exposed for 1–2 h toExpand
Assessment of exposure to butadiene in the process industry.
Occupational exposure levels to 1,3-butadiene (BD) are variable but generally below 1 ppm in the European process industry. A preliminary analysis showed that hemoglobin adduct levels of butadieneExpand
An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers.
A study employing several biomarkers of styrene exposure and genotoxicity was carried out in a group of lamination (reinforced plastic) workers and controls, who had been repeatedly sampled during aExpand
Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides.
Epoxybutanediol is one of the reactive metabolites of butadiene. It is formed via hydrolysis followed by oxidation of the primary metabolite of butadiene, epoxybutene, or via hydrolysis ofExpand
Simultaneous analysis of hemoglobin adducts of acrylamide and glycidamide by gas chromatography-mass spectrometry.
Acrylamide (AA) is a carcinogen in experimental animals. Glycidamide (GA), formed by metabolic epoxidation of AA, is believed to be responsible for the carcinogenicity of AA. Occupational exposure toExpand
Biomonitoring of epichlorohydrin by hemoglobin adducts.
A gas chromatographic mass spectrometric method for monitoring exposure to epichlorohydrin (ECH) by means of quantitative analysis of N-(2,3-dihydroxypropyl)valine in hemoglobin has been developed.Expand
Assessment of environmental and occupational exposures to butadiene as a model for risk estimation of petrochemical emissions.
1,3-Butadiene (BD) is an important industrial chemical and environmental contaminant, e.g. in urban air, traffic exhausts and tobacco smoke. It has been shown to be genotoxic in vitro and in vivo andExpand
An epidemiological study of cancer risk among workers exposed to ethylene oxide using hemoglobin adducts to validate environmental exposure assessments
SummaryCancer morbidity was investigated in a cohort of 2,170 ethylene oxide (EO)-exposed workers from 2 plants producing disposable medical equipment. The subjects had been employed for at least 1Expand
Assessment of the relationship between glucose and A1c using kinetic modeling.
Treatment goals for diabetic patients are directed towards lowering A1c values by controlling blood glucose concentrations (BGC), making it important to understand the relationship between the twoExpand