amperozide

 
National Institutes of Health

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Broader (5)

Antipsychotic AgentsPiperazinesPsychotropic DrugsSerotonin Antagonists
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Highly Cited
1999
Highly Cited
1999
Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens.
The present study was designed to compare the effects of typical and atypical antipsychotic drugs on extracellular dopamine (DA… (More)
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1998
1998
Naltrexone and Amperozide Modify Chocolate and Saccharin Drinking in High Alcohol-Preferring P Rats
Previous studies showed that the 5-HT2 receptor antagonist, amperozide, is somewhat more potent than the opiate antagonist… (More)
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1997
1997
Selective inhibition of alcohol intake in diverse alcohol-preferring rat strains by the 5-HT2A antagonists amperozide and FG 5974.
The present studies sought to elucidate the role of 5-HT2A receptor antagonists in suppressing alcohol intake by comparing the… (More)
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Highly Cited
1996
Highly Cited
1996
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
In preclinical studies, [R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4- piperidinemethanol] [formula: see text… (More)
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Highly Cited
1994
Highly Cited
1994
Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex
The putative atypical antipsychotic drug amperozide (APZ) shows high affinity for serotonin 5-HT2 receptors but only low affinity… (More)
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Highly Cited
1994
Highly Cited
1994
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 (5… (More)
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1992
1992
Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats
The aim of the present study was to investigate whether amperozide, an antipsychotic drug which possesses anti-aggressive and… (More)
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Highly Cited
1992
Highly Cited
1992
Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.
We determined the affinities of clozapine and 21 other typical and atypical antipsychotic agents for the cloned 5… (More)
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1992
1992
Selective reduction by the 5-HT antagonist amperozide of alcohol preference induced in rats by systemic cyanamide
This investigation was undertaken to determine the effect of a unique psychotropic agent on the volitional drinking of alcohol… (More)
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1990
1990
Receptor binding properties of amperozide.
The receptor pharmacology of amperozide was investigated with in vitro radioligand binding technique. Amperozide possessed a high… (More)
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