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Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States
TLDR
Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice, which contributes to depression-like phenotype and reduced behavioral reactions to an antidepressant.
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
TLDR
The results suggest that nicotinic receptors in the somatodendritic region may be of greater importance than those located in the terminal area for the stimulatory action of systemic NIC on the mesolimbic DA system and support the notion that the meslimbic dopaminergic system is phasically rather than tonically regulated by nicotinics receptor activation within the VTA.
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.
TLDR
Virodhamine produced hypothermia in the mouse and acted as an antagonist in the presence of anandamide both in vivo and in vitro, adding a new form of regulation to the endocannabinoid system.
The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone
TLDR
It is proposed that this vesicular synergy between two transmitters is the result of the unbalanced bioenergetics of VAChT, which requires anion co-entry for continuing vesicle filling.
Diverse Psychotomimetics Act Through a Common Signaling Pathway
TLDR
In mice with a genetic deletion of DAR PP-32 or with point mutations in phosphorylation sites of DARPP-32, the effects of D-amphetamine, LSD, and PCP on two behavioral parameters—sensorimotor gating and repetitive movements—were strongly attenuated.
Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release.
TLDR
The results support the notion that nicotinic receptors in the ventral tegmental area may be of greater importance than those located in the nucleus accumbens for mediating some of the stimulatory effects of nicotine on the reward-related mesoaccumbens dopamine system.
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions
TLDR
The results suggest that the cortical selectivity in the release of catecholamines, dopamine in particular, induced by the cannabinoid antagonist SR141716A, its procholinergic properties, together with its mild stimulatory effects on serotonin and norepinephrine efflux make similar compounds unique candidates for the treatment of psychosis, affective and cognitive disorders.
Condition‐independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat
TLDR
Behavioral sensitization after chronic NIC treatment is accompanied by an enhanced dopamine release specifically within the PFC, a phenomenon that may be highly significant for the dependence‐producing effects of NIC, particularly in association with major psychiatric disorder, such as schizophrenia.
Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6 Receptor Stimulation
TLDR
5-HT6 receptor stimulation may be a mechanism initiating some of the biochemical and behavioral outcomes of 5-HT reuptake inhibitors, such as fluoxetine, which indicates that selective 5- HT6 receptor agonists may represent a novel antidepressant drug class.
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