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aminoflavone

Known as: 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Flavonoids

Narrower (1)

NSC 686288

Papers overview

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2016
2016
Abstract 4983: Aminoflavone acts as an immunomodulator of tumor growth in a breast cancer mouse model
Aminoflavone (AFP464, NSC 710464), an antitumor agent which recently entered phase II clinical trials, acts against estrogen… 
Review
2012
Review
2012
Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings
Introduction: Target-specific drugs may offer fewer side/adverse effects in comparison with other anticancer agents and thus save… 
2012
2012
Abstract LB-198: Ryl hydrocarbon receptor agonist Aminoflavone disrupts mammosphere formation via alpha 6 integrin inhibition
Introduction: Emerging evidence has suggested that cancer stem cells (CSCs) play a prominent role in the initiation and… 
2010
2010
Phase I accelerated dose-escalating safety and pharmacokinetic (PK) study of aryl-hydrocarbon receptor-mediated aminoflavone prodrug AFP464 in advanced solid tumors.
2561 Background: AFP464 is a dimethanesulfonate derivative of aminoflavone that has strong anti-tumor activity against a variety… 
2009
2009
Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma.
2008
2008
Cytokeratin-RNA Cross-Linking Mediated by the Antitumor Aminoflavone, 5-Amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
Aminoflavone (AF) is an anticancer drug in early clinical trials, and its antiproliferative activity involves the induction of… 
2008
2008
Cytokeratin-RNA crosslinking mediated by the antitumor aminoflavone, NSC 686288
3283 Aminoflavone (AF) is an anticancer drug in early clinical trials, and its antiproliferative activity involves the induction… 
2007
2007
Breast cancer cells resistant to anti-hormone treatments retain sensitivity to Aminoflavone (NSC 686288)
PR-4 Aminoflavone (AF; NSC 686288) is a novel anticancer agent which has entered phase I clinical trials. AF has shown exquisite… 
2006
2006
CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines
Purpose: Aminoflavone (5-amino-2,3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one; AF; NSC 686288) is a novel… 
2001
2001
Compounds, compositions aminoflavone and use thereof.
Una aminoflavona que tiene la siguiente formula en la que cada R1 y R2 es H, COOH2-R7, en el que R7 es amino, alquilamino de… 
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