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aminochrome 1

Known as: 2,3-dihydro-6-hydroxy-5H-indol-5-one, aminochrome, dopaminochrome 
National Institutes of Health

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Indolequinones

Papers overview

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2009
2009
Molecular and Neurochemical Mechanisms in PD Pathogenesis
Oxidation of dopamine to aminochrome seems to be a normal process leading to aminochrome polymerization to form neuromelanin… 
Highly Cited
2005
Highly Cited
2005
Dopamine-dependent iron toxicity in cells derived from rat hypothalamus.
We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus… 
Review
2002
Review
2002
Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.
Although it is generally accepted that free radicals are involved in the neurodegenerative process occurring in the dopaminergic… 
2000
2000
Enzymatic dopamine peroxidation in substantia nigra of human brain.
1992
1992
Melanin biosynthesis from dopamine. II. A mass spectrometric and collisional spectroscopic investigation.
Electron impact (EI) and fast atom bombardment (FAB) mass spectrometry together with collisional activation (CA) experiments were… 
1991
1991
Specificity of dopachrome tautomerase and inhibition by carboxylated indoles. Considerations on the enzyme active site.
Dopachrome tautomerase (EC 5.3.2.3) catalyses the tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA… 
Highly Cited
1987
Highly Cited
1987
Spectrophotometric and titrimetric determination of catecholamines.
Highly Cited
1984
Highly Cited
1984
Chemical intermediates in dopamine oxidation by tyrosinase, and kinetic studies of the process.
1982
1982
Catechol O-methyltransferase. 12. Affinity labeling the active site with the oxidation products of 5,6-dihydroxyindole.
5,6-Dihydroxyindole (5,6-DHI) and a series of 4- and/or 7-methylated analogues of 5,6-DHI have been synthesized and evaluated for… 
Highly Cited
1972
Highly Cited
1972
6-Hydroxydopamine, a new oxidation mechanism.
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