Specificity of dopachrome tautomerase and inhibition by carboxylated indoles. Considerations on the enzyme active site.

@article{Aroca1991SpecificityOD,
  title={Specificity of dopachrome tautomerase and inhibition by carboxylated indoles. Considerations on the enzyme active site.},
  author={P Aroca and Francisco Solano and Jose Carlos Garcia-Borron and Jos{\'e} A. Lozano},
  journal={The Biochemical journal},
  year={1991},
  volume={277 ( Pt 2)},
  pages={
          393-7
        }
}
Dopachrome tautomerase (EC 5.3.2.3) catalyses the tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) within the melanin-formation pathway. We have analysed a series of substrate analogues and related compounds as possible substrates and inhibitors of tautomerization. The enzyme appears to be highly specific since D-dopachrome, alpha-methyldopachrome, dopaminochrome, adrenochrome methyl ether and deoxyadrenochrome are not substrates. Conversely, dopachrome tautomerase… CONTINUE READING

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