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allocolchicine

Known as: methyl 5-acetylamino-6,7-dihydro-9,10,11-trimethoxy-5H-dibenzo(a,c)cycloheptene-3-carboxylate 
An antimitotic agent that binds to tubulin and inhibits tubulin polymerization and arrests proliferation of tumor cells.
National Institutes of Health

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Related topics

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Broader (1)

Colchicine
Microtubule Processanalogs & derivatives

Papers overview

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2013
2013
An Efficient Combinatorial Synthesis of Allocolchicine Analogues via a Triple Cascade Reaction and their Evaluation as Inhibitors of Insulin Aggregation
A controlled cascade: A divergent, diastereoselective and efficient one-pot synthesis of allocolchicinoids via a cascade Suzuki… 
2006
2006
Application of aryl siloxane cross-coupling to the synthesis of allocolchicinoids.
In this communication, we report a new approach to the allocolchicine carbocyclic skeleton based upon an aryl siloxane coupling… 
2003
2003
Steric vs hydrogen-bonding control of atropisomerization: preparation of either diastereomer of configurationally stable allocolchicinoids.
Steric vs hydrogen-bonding atropisomerization control of configurationally stable analogues of the biaryl natural product… 
2000
2000
Multiple Flexible Alignment with SEAL: A Study of Molecules Acting on the Colchicine Binding Site
An extension of the steric and electrostatic alignment alignment (SEAL) method (MultiSEAL) is described that allows the overlay… 
1998
1998
Distances between the paclitaxel, colchicine, and exchangeable GTP binding sites on tubulin.
Distances between the paclitaxel, colchicine, and exchangeable GTP binding sites on tubulin polymers have been probed using… 
1992
1992
Aging of tubulin at neutral pH: stabilization by colchicine and its analogues.
1991
1991
Roles of ring C oxygens in the binding of colchicine to tubulin.
The roles of the oxygens in ring C of colchicine in its binding to tubulin were probed by a study of the interactions of two… 
1989
1989
A thermodynamic study of the interaction of tubulin with colchicine site ligands.
The bicyclic colchicine analogue 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-on e (MTC) has been used to… 
1988
1988
Energy-transfer studies of the distance between the high-affinity metal binding site and the colchicine and 8-anilino-1-naphthalenesulfonic acid binding sites on calf brain tubulin.
The high-affinity metal divalent cation Mg2+, associated with the exchangeable guanosine 5'-triphosphate (GTP) binding site (E… 
1981
1981
Synthesis and binding to tubulin of an allocolchicine spin probe.
A spin probe for the colchicine binding site on tubulin has been synthesized from allocolchicine. The probe is competitive to… 
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