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alefacept

Known as: alefacept [Chemical/Ingredient], LFA3TIP, LFA-3 IgG(1) fusion protein 
A recombinant dimeric fusion protein consisting of the extracellular CD2-binding domain of the human leukocyte function-associated antigen 3 (LFA-3… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
BACKGROUND The present review is part of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Type 1 diabetes (T1D) results from destruction of pancreatic β cells by autoreactive effector T cells. We hypothesized… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Type 1 diabetes results from autoimmune targeting of the pancreatic β cells, likely mediated by effector memory T (Tem… Expand
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE To evaluate the efficacy and safety of alefacept in combination with methotrexate (MTX) for the treatment of psoriatic… Expand
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Review
2006
Review
2006
Background  Eruptive naevi have been described to potentially arise in immune compromised patients. 
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Highly Cited
2005
Highly Cited
2005
Psoriasis vulgaris, a skin disease that is considered to be the result of a type 1 autoimmune response, provides an opportunity… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Alefacept, human lymphocyte function-associated antigen 3/immunoglobulin 1 fusion protein, binds to CD2 molecules on… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND In previous phase II studies, alefacept significantly improved psoriasis and was well tolerated. The clinical response… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Psoriatic plaques are characterized by infiltration with CD4+ CD45RO+ and CD8+ CD45RO+ memory effector T lymphocytes… Expand
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Highly Cited
1993
Highly Cited
1993
Accessory cell surface molecules, such as T cell antigen CD2 and its ligand lymphocyte function-associated antigen 3 (LFA-3; CD58… Expand
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