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European S3‐Guidelines on the systemic treatment of psoriasis vulgaris
TLDR
Phototherapy represents a safe and very effective treatment option for moderate to severe forms of psoriasis vulgaris and has a good cost-benefit ratio, but the potentially significant costs for, and time required of, the patient must be considered. Expand
Sox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell Compartment
TLDR
It is concluded that although Sox9 is dispensable for hair induction, it directs differentiation of the ORS and is required for the formation of the hair stem cell compartment. Expand
Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial
TLDR
Infliximab is effective in both an induction and maintenance regimen for the treatment of moderate-to-severe psoriasis, with a high percentage of patients achieving sustained PASI 75 and PASi 90 improvement through 1 year. Expand
Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis.
TLDR
Bdalumab significantly improved plaque psoriasis in this 12-week, phase 2 study and was superior to placebo in all comparisons. Expand
Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes
TLDR
The mechanism by which cAMP stimulates tyrosinase expression and melanogenesis is disclosed and the critical role of microphthalmia as signal transducer in cAMP-induced melanogenesis and pigment cell differentiation is emphasized. Expand
Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION)
TLDR
This data indicates that once-weekly dosing with adalimumab is a safe and effective treatment for moderate to severe chronic plaque psoriasis in women with atypical immune response to chemotherapy. Expand
Ras mediates the cAMP‐dependent activation of extracellular signal‐regulated kinases (ERKs) in melanocytes
TLDR
It is shown that Ras, but not Ras, is activated cell‐specifically and mediates the cAMP‐dependent activation of ERKs, while Rap‐1 is not involved in this process in melanocytes, suggesting the existence of a melanocyte‐specific Ras exchange factor directly regulated by cAMP. Expand
Integrin β4 mutations associated with junctional epidermolysis bullosa with pyloric atresia
TLDR
The results implicate mutations in the β4 integrin gene in some forms of PA–JEB, which is a rare inherited disorder characterized by pyloric stenosis and blistering of the skin as primary manifestations. Expand
Different cis-Acting Elements Are Involved in the Regulation of TRP1 and TRP2 Promoter Activities by Cyclic AMP: Pivotal Role of M Boxes (GTCATGTGCT) and of Microphthalmia
TLDR
In B16 melanoma cells, it is demonstrated that stimulation of melanogenesis by cAMP-elevating agents results in an increase in tyrosinase, TRP1, and TRP2 expression and it is found that microphthalmia, a basic helix-loop-helix transcription factor, strongly stimulates the transcriptional activities of the TRP 1 and TRp2 promoters, mainly through binding to the M boxes. Expand
A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis.
TLDR
Briakinumab showed higher efficacy than methotrexate in patients with moderate-to-severe psoriasis, and serious infections and cancers occurred more frequently with briakinumabs, but the differences were not significant. Expand
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