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aggregin

 
National Institutes of Health

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Broader (1)

Platelet Membrane Glycoproteins

Papers overview

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Highly Cited
2001
Highly Cited
2001
P2y(12), a new platelet ADP receptor, target of clopidogrel.
The binding characteristics of (33)P-2MeS-ADP, a stable analogue of ADP, were determined on CHO cells transfected with the human… Expand
1995
1995
Inhibition of ADP-induced Platelet Responses by Covalent Modification of Aggregin, a Putative ADP Receptor, by 8-(4-Bromo-2,3-dioxobutylthio)ADP (*)
ADP is an important platelet agonist which initiates platelet shape change, aggregation, exposure of fibrinogen receptors, and… Expand
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Highly Cited
1992
Highly Cited
1992
Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase.
Clopidogrel, like the homologous thienopyridine derivative ticlopidine, selectively inhibits platelet aggregation induced by ADP… Expand
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Highly Cited
1991
Highly Cited
1991
High molecular weight kininogen inhibits thrombin-induced platelet aggregation and cleavage of aggregin by inhibiting binding of thrombin to platelets.
In this study we show that high molecular weight kininogen (HK) inhibited alpha-thrombin-induced aggregation of human platelets… Expand
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Review
1990
Review
1990
Aggregin: a platelet ADP receptor that mediates activation
  • R. Colman
  • FASEB journal : official publication of the…
  • 1990
    • Corpus ID: 41897048
ADP is known to induce platelet shape change, aggregation, and exposure of fibrinogen binding sites as well as inhibit stimulated… Expand
1990
1990
Plasmin-induced platelet aggregation is accompanied by cleavage of aggregin and indirectly mediated by calpain.
We recently reported that thrombin-induced platelet aggregation 1) is accompanied by cleavage of aggregin, a 100-kDa membrane… Expand
1990
1990
Aggregin: a platelet ADP receptor that mediates
ADP is known to induce platelet shape change, aggregation, and exposure of fibrinogen binding sites as well as inhibit stimulated… Expand
Highly Cited
1989
Highly Cited
1989
Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain.
5'-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change… Expand
1989
1989
Cleavage of a 100 kDa membrane protein (aggregin) during thrombin-induced platelet aggregation is mediated by the high affinity thrombin receptors.
Thrombin-induced platelet aggregation is accompanied by cleavage of aggregin, a surface membrane protein (Mr = 100 kDa), and is… Expand
1988
1988
Distinction between glycoprotein IIIa and the 100-kDa membrane protein (aggregin) mediating ADP-induced platelet activation.
Previous studies from our laboratories showed that 5'-p-fluorosulfonylbenzoyl adenosine (FSBA) inhibits ADP-induced platelet… Expand
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