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aditoprim

Known as: 2,4-diamino-5-(4-(dimethylamino)-3,5-dimethoxybenzyl)pyrimidine 
A long-acting, selective, reversible inhibitor of dihydrofolate reductase with application as a broad-spectrum antibacterial agent in animals.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Folic Acid AntagonistsTrimethoprim
analogs & derivativespelargonic acid

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Two‐generation reproduction and teratology studies of feeding aditoprim in Wistar rats
Aditoprim, a new bacteriostatic agent that belongs to diaminopyrimidines, has a broad antimicrobial spectrum, good antibacterial… 
2015
2015
Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies
Aditoprim (ADP), a new developed dihydrofolate reductase (DHFR) inhibitor, has great potential in clinical veterinary medicine… 
1992
1992
Effects of endotoxin-induced mastitis on the pharmacokinetic properties of aditoprim in dairy cows.
Plasma disposition of aditoprim, a new dihydrofolate reductase inhibitor, was studied in healthy cows and cows with endotoxin… 
1991
1991
Pharmacokinetics of aditoprim in dogs after intravenous and oral administration: a preliminary study
The pharmacokinetics of aditoprim (2,4-diam-ino-5-[4-[dimethylamino]-3,5-dimethoxybenzyl] pyrimidine), a dihydrofolate reductase… 
1990
1990
Plasma disposition and tolerance of aditoprim in horses after single intravenous injection.
Aditoprim, a broad spectrum antimicrobial agent acting as a reversible dihydrofolate reductase inhibitor, was intravenously… 
1990
1990
In vitro susceptibility of some porcine respiratory tract pathogens to aditoprim, trimethoprim, sulfadimethoxine, sulfamethoxazole, and combinations of these agents.
The in vitro antimicrobial activities of aditoprim (AP), a new dihydrofolate reductase (DHFR) inhibitor, trimethoprim (TMP… 
1990
1990
In vitro activity of flumequine in comparison with several other antimicrobial agents against five pathogens isolated in calves in The Netherlands.
The in vitro activity of flumequine in comparison with several other drugs was tested against 17 P. multocida, 16 P. haemolytica… 
1988
1988
Some pharmacokinetic data of aditoprim and trimethoprim in healthy and tick-borne fever infected dwarf goats.
Aditoprim (AP) is a new dihydrofolate reductase inhibitor, which is structurally related to trimethoprim (TMP). The… 
1988
1988
Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor.
Summary The affinity of aditoprim (ADM), a new selective inhibitor of bacterial dihydrofolate reductases (DHFR), was two- to… 
1987
1987
Pharmacokinetics of aditoprim, a new long-acting dihydrofolate reductase inhibitor, in heifers.
Summary The pharmacokinetics of aditoprim, a new dihydrofolate reductase (DHFR) inhibitor, and trimethoprim (TMP) were studied… 
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