Pharmacokinetics of aditoprim in dogs after intravenous and oral administration: a preliminary study

  title={Pharmacokinetics of aditoprim in dogs after intravenous and oral administration: a preliminary study},
  author={H. Sutter and B. Ludwig and K. Bremer and J. Jordan and W. Rehm and M. Wanner},
  journal={Journal of Small Animal Practice},
  • H. Sutter, B. Ludwig, +3 authors M. Wanner
  • Published 1991
  • Medicine
  • Journal of Small Animal Practice
  • The pharmacokinetics of aditoprim (2,4-diam-ino-5-[4-[dimethylamino]-3,5-dimethoxybenzyl] pyrimidine), a dihydrofolate reductase inhibitor, were studied in three eight to 17-month-old beagle dogs. The drug was alternately injected intravenously and administered orally as a tablet in two separate experiments. The doses ranged from 4–27 to 7–25 mg/kg bodyweight. The mean plasma clearance (CI) was 15-3 ml/min/kg and the mean volume of distribution (Vss) 13-1 litres/kg. The mean plasma elimination… CONTINUE READING
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