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Experience programs synaptic development to match the needs of the environment. This process depends on the nature and timing of… Expand We have examined the anxiolytic activity of acute and chronic antidepressant treatment in an animal model of anxiety involving… Expand The open field is a very popular animal model of anxiety-like behavior. An overview of the literature on the action elicited by… Expand Both repeated stress and corticosterone administration induce remodeling of apical dendrites of hippocampal CA3 pyramidal neurons… Expand Mean effect sizes for changes in depression were calculated for 2,318 patients who had been randomly assigned to either… Expand The olfactory bulbectomized (OB) rat has been proposed as an animal model of depression. The following behavioural changes have… Expand Several lines of evidence have established that performance during the initial steps of acquisition on a shuttle-box avoidance… Expand Corticotropin‐releasing factor (CRF) is the major physiological regulator of the hypothalamic‐pituitary‐adrenal (HPA) axis… Expand Results of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments… Expand Adinazolam, which is a 1-dimethylaminomethyl triazolobenzodiazepine, is an effective anxiolytic agent as defined by suppression… Expand