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adapalene

Known as: 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, Adapalene [Chemical/Ingredient], 6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid 
A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific… 
National Institutes of Health

Related topics

Related topics

18 relations
Acne VulgarisDrug AllergyIn BloodRetinoids

Narrower (4)

AdaferinCD-271DifferinEpiduo

Broader (2)

Anti-Inflammatory Agents, Non-SteroidalDermatologic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Long-term safety and efficacy study of adapalene 0.3% gel.
The efficacy and safety of adapalene 0.1% gel in the treatment of acne vulgaris has been demonstrated in multiple controlled… 
2005
2005
Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study.
A multicenter, double-blind, randomized, parallel-group trial compared tazarotene 0.1% cream with adapalene 0.1% cream, once… 
2005
2005
Benzoyl Peroxide, Adapalene, and Their Combination in the Treatment of Acne Vulgaris
Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment of acne. We planned an open… 
2005
2005
Cumulative irritation potential of adapalene 0.1% cream and gel compared with tazarotene cream 0.05% and 0.1%.
Despite the many beneficial effects of dermatologic applications, most of the current treatments for acne cause local irritation… 
2004
2004
Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A…
Background  Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first‐line… 
Highly Cited
2003
Highly Cited
2003
13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?
2002
2002
Comparison of the effects of tretinoin, adapalene and collagenase in an experimental model of wound healing.
Adapalene is a new naphthoic acid derivative with strong retinoid agonistic pharmacological properties. We propose that adapalene… 
2001
2001
Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.
A prior meta-analysis of 5 randomized controlled trials indicates that adapalene gel 0.1% is as effective as tretinoin gel 0.025… 
1997
1997
The treatment of acne with topical retinoids: one man's opinions.
Review
1993
Review
1993
Topical retinoids. Their uses in dermatology.
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