Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator‐masked, controlled trial

@article{Capizzi2004SkinTA,
  title={Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator‐masked, controlled trial},
  author={Rodolfo Capizzi and F Landi and Massimo Milani and Paolo Amerio},
  journal={British Journal of Dermatology},
  year={2004},
  volume={151}
}
Background  Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first‐line treatment for acne vulgaris (AV). However, these combinations could have a suboptimal skin tolerability. Recently, a new formulation of hydrogen peroxide (HP) 1% in stabilized cream (Crystacide®; Mipharm, Milan, Italy) became available. A previous clinical study has shown that HP cream monotherapy presents a better skin tolerability in comparison with BP in patients… 
Evaluation of safety and efficacy of hydrogen peroxide stabilized cream for treatment of mild to moderate acne vulgaris in comparison with benzoyl peroxide gel - double blinded, randomized control study
TLDR
In acne grade one and two benzoyl peroxide and hydrogen peroxide are equally efficacious though hydrogenperoxide has less adverse effect and Hydrogen peroxide group experienced less side-effects as compared to benzoyL peroxidegroup.
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Invention ensures achievement of stable positive effect in long-term treatment of acne with composition, including adapalene and benzoyl peroxide, as well as absence of side effects.
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TLDR
Based on low-certainty evidence, there may be little to no difference between BPO and adapalene, and for 'participant-reported acne improvement', BPO may be more effective than placebo or no treatment.
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Plai gel is promising to be used in treatment of mild to moderate acne, which the effect could be seen within the first month as compared to placebo, and was safe.
Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.
TLDR
A novel hydrogen peroxide-based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide -based regimen in the treatment of mild-to-moderate acne.
Is topical treatment with Crystavet® an effective treatment of Malassezia overgrowth in dogs?
TLDR
Topical treatment with Crystavet (1% hydrogen peroxide) is effective and safe for the treatment of localized Malassezia overgrowth in dogs and the results suggest that the antifungal efficacy of 1% Hydrogen peroxide is similar to that of 4% chlorhexidine for MalasseZia species.
Enzymatically generated hydrogen peroxide reduces the number of acne lesions in acne vulgaris.
TLDR
A hydrogen peroxide generation system using the enzyme glucose oxidase and glucose, stable in a simple formulation and nonirritating, was effective in reducing the individual lesion size and total number of inflammatory acne lesions in a short-term and long-term clinical study.
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TLDR
Retapamulin, a novel topical antibacterial agent, will probably replace the use of the old mupirocin and fusidic acid in the management of acne and atopic dermatitis.
Evaluation of LHP® (1% hydrogen peroxide) cream versus petrolatum and untreated controls in open wounds in healthy horses: a randomized, blinded control study
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Treatment with LHP® cream reduced bacterial colonization and was associated with earlier complete wound healing, and appears to be safe and effective for topical wound treatment or wound protection.
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