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Management of acne: a report from a Global Alliance to Improve Outcomes in Acne.
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New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group.
The Global Alliance to Improve Outcomes in Acne published recommendations for the management of acne as a supplement to the Journal of the American Academy of Dermatology in 2003. The recommendationsExpand
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Guidelines of care for acne vulgaris management.
DISCLAIMER Adherence to these guidelines will not ensure successful treatment in every situation. Furthermore, these guidelines should not be deemed inclusive of all proper methods of care orExpand
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Thematic review series: Skin Lipids. Sebaceous gland lipids: friend or foe? Published, JLR Papers in Press, November 1, 2007.
Sebaceous glands are intriguing glands that are found throughout the human body except on the palms of the hands and soles of the feet. The true function of these glands has yet to be determined, butExpand
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Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee
&NA; In 2002, the National Rosacea Society assembled an expert committee to develop the first standard classification of rosacea. This original classification was intended to be updated as scientificExpand
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Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1).
Although the human sebaceous gland can synthesize cholesterol from acetate and can further metabolize steroids such as dehydroepiandrosterone into potent androgens, the de novo production of steroidsExpand
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Cutaneous androgen metabolism: basic research and clinical perspectives.
The skin, especially the pilosebaceous unit composed of sebaceous glands and hair follicles, can synthesize androgens de novo from cholesterol or by locally converting circulating weaker androgens toExpand
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The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.
BACKGROUND Data suggest that androgenetic alopecia is a process dependent on dihydrotestosterone (DHT) and type 2 5alpha-reductase. Finasteride is a type 2 5alpha-reductase inhibitor that has beenExpand
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Finasteride in the treatment of men with frontal male pattern hair loss.
BACKGROUND Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss.Expand
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IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway.
Understanding the factors that regulate sebum production is important in identifying therapeutic targets for acne therapy. Insulin and IGF-1 stimulate sebaceous gland lipogenesis. IGF-1 increasesExpand
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