acylfulvene
National Institutes of Health
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The efficacy of DNA-damaging anticancer drugs is highly influenced by cellular DNA repair capacity, and by inhibiting the…
Acylfulvenes (AFs), a class of semisynthetic analogues of the sesquiterpene natural product illudin S, are cytotoxic toward…
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC
Irofulven (NSC 683863), a semi-synthetic analog of…
University of Minnesota M.S. thesis. December 2009. Major: Medicinal Chemistry. Advisor: Professor Shana J. Sturla, Ph.D. 1…
BackgroundThe purpose of this study was to evaluate the tolerability and efficacy of irofulven, a DNA interacting acylfulvene…
14105 Background: Cytotoxic chemotherapy has been widely used in patients (pts) with advanced or metastatic gastric cancer, but…
You OBTAIN A method for inhibiting the growth of a tumor cell in a subject comprising contacting the tumor with an amount…
High performance liquid chromatography (HPLC) combined with effective preseparation steps (liquid extraction, solid-phase…