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acylfulvene

 
National Institutes of Health

Papers overview

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2013
2013
Illudin S and its semisynthetic analogue acylfulvene (AF) are structurally similar but elicit different biological responses. AF… Expand
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2010
2010
Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6… Expand
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2010
2010
Illudin S and M (1, 2) are highly toxic sesquiterpenes found in the basidiomycete Omphalotus illudens. Illudins have a low… Expand
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2007
2007
Acylfulvenes (AFs) are a class of semisynthetic agents with high toxicity toward certain tumor cells, and for one analogue… Expand
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2007
2007
Acylfulvenes (AFs) are a class of antitumor agents that exert their cytotoxic effects by forming covalent adducts with… Expand
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2006
2006
Acylfulvenes comprise a family of semisynthetic natural product derivatives with potent antitumor activities. Previous studies… Expand
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2005
2005
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to… Expand
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1999
1999
Purpose: The acylfulvenes are a class of antitumor agents derived from the fungal toxin illudin S. One acylfulvene derivative… Expand
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1996
1996
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The… Expand
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1995
1995
Four second-generation Illudin analogues were synthesized and tested for antitumor activity using a metastatic lung carcinoma… Expand
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