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acylfulvene

National Institutes of Health

Papers overview

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2013
2013
Illudin S and its semisynthetic analogue acylfulvene (AF) are structurally similar but elicit different biological responses. AF… 
2010
2010
Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6… 
2010
2010
Illudin S and M (1, 2) are highly toxic sesquiterpenes found in the basidiomycete Omphalotus illudens. Illudins have a low… 
2007
2007
Acylfulvenes (AFs) are a class of semisynthetic agents with high toxicity toward certain tumor cells, and for one analogue… 
2007
2007
Acylfulvenes (AFs) are a class of antitumor agents that exert their cytotoxic effects by forming covalent adducts with… 
2006
2006
Acylfulvenes comprise a family of semisynthetic natural product derivatives with potent antitumor activities. Previous studies… 
Highly Cited
1996
Highly Cited
1996
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The… 
1996
1996
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to… 
Highly Cited
1995
Highly Cited
1995
Four second-generation Illudin analogues were synthesized and tested for antitumor activity using a metastatic lung carcinoma…