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acylfulvene

 
National Institutes of Health

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2 relations

Broader (2)

SesquiterpenesSpiro Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities.
Illudin S and its semisynthetic analogue acylfulvene (AF) are structurally similar but elicit different biological responses. AF… Expand
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2010
2010
Inhibiting tumor growth by targeting tumor vasculature with galectin-1 antagonist anginex conjugated to the cytotoxic acylfulvene, 6-hydroxylpropylacylfulvene.
Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6… Expand
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2010
2010
Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene.
Illudin S and M (1, 2) are highly toxic sesquiterpenes found in the basidiomycete Omphalotus illudens. Illudins have a low… Expand
2007
2007
Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent.
Acylfulvenes (AFs) are a class of semisynthetic agents with high toxicity toward certain tumor cells, and for one analogue… Expand
2007
2007
Quantitative correlation of drug bioactivation and deoxyadenosine alkylation by acylfulvene.
Acylfulvenes (AFs) are a class of antitumor agents that exert their cytotoxic effects by forming covalent adducts with… Expand
2006
2006
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
Acylfulvenes comprise a family of semisynthetic natural product derivatives with potent antitumor activities. Previous studies… Expand
2005
2005
Acylfulvenes, a new class of potent antitumor agents
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to… Expand
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1999
1999
Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines
Purpose: The acylfulvenes are a class of antitumor agents derived from the fungal toxin illudin S. One acylfulvene derivative… Expand
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Highly Cited
1996
Highly Cited
1996
(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties.
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The… Expand
Highly Cited
1995
Highly Cited
1995
Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and…
Four second-generation Illudin analogues were synthesized and tested for antitumor activity using a metastatic lung carcinoma… Expand
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