acylfulvene

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
02419922017

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2013
2013
Illudin S and its semisynthetic analogue acylfulvene (AF) are structurally similar but elicit different biological responses. AF… (More)
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2010
2010
Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6… (More)
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2010
2010
Illudin S and M (1, 2) are highly toxic sesquiterpenes found in the basidiomycete Omphalotus illudens. Illudins have a low… (More)
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2007
2007
Acylfulvenes (AFs) are a class of semisynthetic agents with high toxicity toward certain tumor cells, and for one analogue… (More)
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1999
1999
Illudins are novel compounds from which a potent class of antitumor agents, called acylfulvenes, have been synthesized. The model… (More)
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1997
1997
Purpose: Acylfulvene derivatives demonstrate marked efficacy in xenograft carcinoma models as compared with the parent illudin… (More)
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1996
1996
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The… (More)
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1996
1996
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to… (More)
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1995
1995
Four second-generation Illudin analogues were synthesized and tested for antitumor activity using a metastatic lung carcinoma… (More)
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1992
1992
High performance liquid chromatography (HPLC) combined with effective preseparation steps (liquid extraction, solid-phase… (More)
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