• Publications
  • Influence
A synthetic nucleoside probe that discerns a DNA adduct from unmodified DNA.
  • J. Gong, S. Sturla
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 3 April 2007
This study provides the first example of a thermodynamically stable DNA base pair that is comprised of a biologically relevant carcinogen−DNA adduct and a synthetic nucleoside probe. Expand
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
Data support the role of AOR-mediated metabolism and indicate the involvement of other stereochemically dictated pathways, such as transport and biomolecule binding, in contributing to the cytotoxicity of acylfulvenes. Expand
Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID.
A novel quantitative method utilizing LC-MS/MS coupled with in-source CID that is highly selective and sensitive to PEG-related materials is reported that enables further studies for a thorough characterization of disposition and fate of PEGylated proteins. Expand
Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition
Findings provide further evidence supporting the translational value of CPI and CPIII as suitable endogenous clinical probes to gauge OATP1B activity and potential for OATp1B-mediated DDIs. Expand
Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
Overall, multiple enzymes are involved in the metabolism of brivanib, suggesting a low potential for drug-drug interactions either through polymorphism or through inhibition of a particular drug-metabolizing enzyme. Expand
Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans
  • J. Gong, T. Eley, +7 authors Wenying Li
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 2 January 2016
In bile and feces, intact ASV was a prominent radioactive peak suggesting that both metabolism and direct excretion played important roles in ASV clearance and the primary metabolic pathways of ASV were hydroxylation, sulfonamide hydrolysis and the loss of isoquinoline. Expand
Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent.
In AF-treated cells that were transfected with either AOR or control vectors, theDNA adducts identified match those from in vitro studies, and a positive correlation was observed between DNA adduct levels and cell sensitivity to AF. Expand
Quantitative correlation of drug bioactivation and deoxyadenosine alkylation by acylfulvene.
A sensitive HPLC-ESI-MS/MS method is reported for quantitation of the major DNA adduct induced by AF and illustrates a correlation between N3-AF-Ade formation and AOR-mediated enzymatic activation in a cell-free system, thus providing a template for further studies of drug toxicity in cells and in vivo. Expand
Metabolism, Excretion, and Pharmacokinetics of Oral Brivanib in Patients with Advanced or Metastatic Solid Tumors
Brivanib alaninate was rapidly absorbed and extensively metabolized after a single 800-mg oral dose; the majority of drug-related radioactivity was excreted in feces. Expand
A new macrocycle demonstrates ditopic recognition properties.
  • J. Gong, B. Gibb
  • Chemistry, Medicine
  • Chemical communications
  • 7 March 2005
The synthesis and binding properties of a new macrocycle is reported. The host, comprised of three basic pyridines, four hydrogen bond accepting carbonyls, and two hydrogen bond donating amideExpand