actinonin

 
National Institutes of Health

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2011
2011
Sepsis-induced acute kidney injury occurs in 20% to 50% of septic patients and nearly doubles the mortality rate of sepsis… (More)
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2008
2008
We investigated the effects of actinonin, an inhibitor of a matrix-degrading enzyme meprin, on ischemic acute kidney injury in… (More)
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Review
2006
Review
2006
Natural products have played a pivotal role in antibiotic drug discovery with most antibacterial drugs being derived from a… (More)
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2005
2005
We have previously shown that actinonin causes inhibition of cellular proliferation in U937 leukemia cells. In this report we… (More)
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2004
2004
Peptide deformylase activity was thought to be limited to ribosomal protein synthesis in prokaryotes, where new peptides are… (More)
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2003
2003
Peptide deformylases (PDFs) have been investigated as potential specific targets for antibiotics, but the possible existence of a… (More)
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2002
2002
The antiproliferative effects of bestatin and actinonin on U937 and K562 cells have been compared with their inhibitory activity… (More)
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Highly Cited
2000
Highly Cited
2000
Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the… (More)
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1998
1998
Actinonin, an antibiotic and CD13/aminopeptidase N (APN) inhibitor, has been shown to be cytotoxic to tumor cell lines in vitro… (More)
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1962
1962
DURING a programme of screening of soil and other materials to select antibiotically active microorganisms, Drs. R. Green and R… (More)
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