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Epithelial-mesenchymal transition in ovarian cancer.
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Involvement of Mytilins in Mussel Antimicrobial Defense*
TLDR
In an experimental model of infection, it is shown that a recruitment of hemocytes containing mytilins toward the injection site within hours following bacterial challenge, and that my tilins probably play a prominent role in killing intracellular bacteria after phagocytosis, and later an increase of mytilin-like material occurred in the plasma suggesting a secondary systemic role.
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Presence and regulation of the endocannabinoid system in human dendritic cells.
TLDR
It is demonstrated for the first time that the endogenous cannabinoid system is present in human dendritic cells and can be regulated by cell activation.
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Direct Detection of Alternative Open Reading Frames Translation Products in Human Significantly Expands the Proteome
TLDR
The results imply that coding of multiple proteins in a single gene by the use of AltORFs may be a common feature in eukaryotes, and confirm that translation of unconventional ORFs generates an as yet unexplored proteome.
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Direct analysis and MALDI imaging of formalin-fixed, paraffin-embedded tissue sections.
TLDR
Two methods for the direct analysis of formalin-fixed, paraffin-embedded (FFPE) tissues by MALDI-MS are presented, based on the use of a reactive matrix, 2,4-dinitrophenylhydrazine, useful for FFPE tissues stored less than 1 year.
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Solid ionic matrixes for direct tissue analysis and MALDI imaging.
TLDR
New technical developments for the direct tissue analysis of peptides with ionic liquid made of matrix mixtures and a new outlook on peptide tissue profiling by MS, characterization of compounds from tissue slices, and MALDI-MS high-quality imaging are presented.
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Microbial Challenge Promotes the Regenerative Process of the Injured Central Nervous System of the Medicinal Leech by Inducing the Synthesis of Antimicrobial Peptides in Neurons and Microglia12
TLDR
The leech CNS appears as an excellent model for studying the implication of immune molecules in neural repair after trauma, and is the first to report the neuronal synthesis of antimicrobial peptides and their participation in the immune response and the regeneration of the CNS.
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The nervous system and innate immunity: the neuropeptide connection.
TLDR
Recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, might directly defend the host from microbial assault are discussed.
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Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor.
TLDR
A physiological dose of estrogen acutely stimulates NO release from human monocytes via the activation of an estrogen surface receptor that is coupled to increases in intracellular calcium.
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Antimicrobial peptides from animals: focus on invertebrates.
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