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Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-β1 Secretion In Vivo1
CD26 or dipeptidyl peptidase IV (DP IV) is expressed on various cell types, including T cells. Although T cells can receive activating signals via CD26, the physiological role of CD26/DP IV isExpand
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Propolis and Some of its Constituents Down-Regulate DNA Synthesis and Inflammatory Cytokine Production but Induce TGF-β1 Production of Human Immune Cells
Abstract Propolis, the resinous product collected by honey bees from plants, is used as folk medicine since ancient time. Recently, immunoregulatory and anti-inflammatory properties of propolis haveExpand
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Functional role of CD26 on human B lymphocytes.
CD26 is a well-known activation marker on T cells and natural killer (NK) cells [1]. It is identical with the ectopeptidase dipeptidyl peptidase IV (DP IV). The expression of CD26 on B cells has beenExpand
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Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn’s disease
Backround and aims: The aetiopathogenesis of Crohn’s disease, an inflammatory bowel disease (IBD), is not yet fully understood. Autoimmune mechanisms are thought to play a role in the development ofExpand
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Evidence for a crucial role of neutrophil‐derived serine proteases in the inactivation of interleukin‐6 at sites of inflammation
The bioactivity of interleukin‐6 (IL‐6) was found to be dramatically reduced in fluids from sites of inflammation. Here, we provide evidence that the neutrophil‐derived serine proteases elastase,Expand
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Astrocyte gp130-expression is critical for the control of Toxoplasma encephalitis
Toxoplasma gondii infects astrocytes, neurons and microglia cells in the CNS and, after acute encephalitis, persists within neurons. Robust astrocyte activation is a hallmark of ToxoplasmaExpand
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Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation
Astrocytes are activated in experimental autoimmune encephalomyelitis (EAE) and have been suggested to either aggravate or ameliorate EAE. However, the mechanisms leading to an adverse or protectiveExpand
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Review: the role of membrane peptidases in immune functions.
Uwe Lendeckel, Thilo Kahne, Dagmar Riemann, Klaus Neubert, Marco Arndt and Dirk Reinhold Institute of Experimental Internal Medicine, Center of Internal Medicine, Otto-von-Guericke UniversityExpand
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Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease.
BACKGROUND Crohn's disease (CD) is an inflammatory bowel disease (IBD) characterized by reactivity against microbial and self antigens. Zymogen granule glycoprotein 2 (GP2) was identified as theExpand
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DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system. Peptidases like dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) play aExpand
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