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acodazole

Known as: 1H-imidazo[4,5-f]quinoline, acetamide deriv, acetamide, N-methyl-N-[4-[(7-methyl-1H-imidazo[4, 5-f]quinolin-9-yl)amino]phenyl]- 
A synthetic imidazoquinoline with antineoplastic activity. Acodazole intercalates into DNA, resulting in disruption of DNA replication. Use of this… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

AminoquinolinesImidazoles
NCIt Antineoplastic Agent Terminologyacodazole monohydrochloride

Papers overview

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2015
2015
Mechanistic Investigation of Copper ( II )-Catalyzed Oxidation of L-Asparagine by Hexachloroplatinate ( IV ) in Aqueous Alkaline Medium : A Kinetic Approach
Kinetics and mechanistic investigations of copper(II)-catalyzed oxidation of L-asparagine (Asn) by hexachloroplatinate(IV) (HCP… 
2009
2009
Estimation on the intramolecular 10‐membered ring NH···OC hydrogen‐bonding energies in glycine and alanine peptides
Computation of accurate intramolecular hydrogen‐bonding energies for peptides is of great importance in understanding the… 
2009
2009
Novel 4(3H)-Quinazolinone Containing Biologically Active Thiazole, Pyrazole, 1,3-dithiazole, Pyridine, Chromene, Pyrazolopyrimidine and Pyranochromene of Expected Biological Activity
2 Abstract: Diazotization of 2-cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl) acetamide 2 with the desired diazonium chloride… 
Highly Cited
1997
Highly Cited
1997
Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.
A novel probe, N-(2-hydroxy-3,3,3,-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554), has been used to detect tumor… 
Review
1996
Review
1996
CCKB/gastrin receptor antagonists: recent advances and potential uses in gastric secretory disorders.
Cholecystokinin (CCK) and the structurally related peptide, gastrin, have numerous effects on tissues in the central nervous… 
1985
1985
Persistence of sister chromatid exchanges and in vitro morphological transformation of Syrian hamster fetal cells by chemical and physical carcinogens.
The induction of neoplastic cell transformation is closely associated with DNA alterations which occur shortly after carcinogen… 
1985
1985
Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications.
The ability of Sn(tin)-protoporphyrin to inhibit the induction of hepatic delta-aminolevulinate (ALA) synthase by allylisopropyl… 
1984
1984
Correlation of morphological transformation to sister chromatid exchanges induced by split doses of chemical or physical carcinogens on cultured Syrian hamster cells.
The relationship between the induction of DNA damage as reflected by sister chromatid exchange (SCE) formation and morphological… 
1983
1983
New inhibitors of alcohol dehydrogenase: studies in vivo and in vitro in the rat.
Two compounds bearing an amide group, p-butoxyphenol acetamide (BPA) and N-(p-butoxybenzyl)formamide (BBF) were studied as… 
Highly Cited
1981
Highly Cited
1981
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.
We have determined the dose-response curves (100-900 mg of Fe/kg body wt.) and the time course over 84 days for the effects of a…