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acodazole

Known as: 1H-imidazo[4,5-f]quinoline, acetamide deriv, acetamide, N-methyl-N-[4-[(7-methyl-1H-imidazo[4, 5-f]quinolin-9-yl)amino]phenyl]- 
A synthetic imidazoquinoline with antineoplastic activity. Acodazole intercalates into DNA, resulting in disruption of DNA replication. Use of this… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

AminoquinolinesImidazoles
NCIt Antineoplastic Agent Terminologyacodazole monohydrochloride

Papers overview

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Highly Cited
2010
Highly Cited
2010
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.
Highly Cited
2008
Highly Cited
2008
Poly(amidoamine) dendrimers on lipid bilayers I: Free energy and conformation of binding.
Third-generation (G3) poly(amidoamine) (PAMAM) dendrimers are simulated approaching 1,2-dimyristoyl- sn-glycero-3-phosphocholine… 
2006
2006
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis…
The peripheral benzodiazepine receptor (PBR) is widely expressed in peripheral tissues, blood cells, and in glia cells in the… 
Review
2003
Review
2003
New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?
Purpose of reviewValproic acid (VPA) is one of the four first line antiepileptic drugs (AEDs). VPA is also an effective drug in… 
Highly Cited
1998
Highly Cited
1998
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
We have addressed the key deficiency of noncovalent pyridinone acetamide thrombin inhibitor L-374,087 (1), namely, its modest… 
1998
1998
Effect of cation-exchange pretreatment of aqueous soil extracts on the gas chromatographic-mass spectrometric determination of nerve agent hydrolysis products after tert.-butyldimethylsilylation.
Review
1998
Review
1998
Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non…
Hypoxia occurs to a variable extent in a vast majority of rodent and human solid tumors. It results from an inadequate and… 
Highly Cited
1997
Highly Cited
1997
Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.
A novel probe, N-(2-hydroxy-3,3,3,-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554), has been used to detect tumor… 
Highly Cited
1981
Highly Cited
1981
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.
We have determined the dose-response curves (100-900 mg of Fe/kg body wt.) and the time course over 84 days for the effects of a… 
Highly Cited
1972
Highly Cited
1972
Effect of dietary selenium on N-2 fluorenyl-acetamide (FAA)-induced cancer in vitamin E supplemented, selenium depleted rats.
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