• Publications
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PERICONCEPTIONAL MULTIVITAMIN USE IN RELATION TO THE RISK OF CONGENITAL URINARY TRACT ANOMALIES
TLDR
Prenatal multivitamin use, particularly during the first trimester, may reduce the risk of a CUTA, and all of the preparations taken by study participants contained many vitamins as well as folic acid. Expand
Culture of whole rodent embryos in teratogen screening.
  • A. Fantel
  • Biology, Medicine
  • Teratogenesis, carcinogenesis, and mutagenesis
  • 1982
TLDR
Because studies have shown the importance of maternal metabolism in the activation and inactivation of teratogens, it is hoped that these systems will enable us to understand the biochemical basis of species variability in teratogenic sensitivity and construct a teratogen screen which can reliably identify compounds which pose Teratogenic hazards to humans. Expand
Catalysis of the 4-hydroxylation of retinoic acids by cyp3a7 in human fetal hepatic tissues.
TLDR
The results indicated that the 4-hydroxylation of RA, catalyzed prenatally by CYP3A7, might play an important role in protecting the human fetus against RA-induced embryotoxicity. Expand
Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain.
TLDR
There was a dramatic increase in human brain CYP2E1 content around gestational day 50 and a fairly constant level was maintained throughout the early fetal period, until at least day 113, suggesting that the relatively low levels of the P-450 isoform present in conceptal brain may be sufficient to generate reactive intermediates that elicit neuroembryotoxicity following maternal alcohol consumption. Expand
Direct embryotoxicity of cocaine in rats: effects on mitochondrial activity, cardiac function, and growth and development in vitro.
TLDR
It is proposed that compromised energy supplies form the basis of the developmental toxicity of cocaine, and that placental vasoconstriction limits the ability of embryos to meet the increased glucose demands induced by hypoxia. Expand
Reactive oxygen species and DNA oxidation in fetal rat tissues.
TLDR
Formation of ROS in teratogenically sensitive limb and brain and insensitive heart before and during the period of teratogenic sensitivity and DNA hydroxylation in sensitive and insensitive fetal tissues during uteroplacental ischemia and reperfusion in vivo are examined. Expand
A new technique for culturing rat embryos between gestation days 14 and 15.
TLDR
A method for culturing rat embryos between days 14 and 15 has been developed and embryonic growth and development were similar to that in in vivo controls, and viability was high. Expand
Further evidence for the role of free radicals in the limb teratogenicity of L-NAME.
TLDR
Findings support the role of excess reactive oxygen species (ROS) formation in L-NAME-induced limb reduction and propose that nitric oxide (NO) depletion by L- NAME interferes with vascular integrity, and causes vasoconstriction. Expand
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