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aclacinomycin

National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Aclacinomycin (Acl) oxidoreductase (AknOx) catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the Acl… Expand
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Highly Cited
2005
Highly Cited
2005
During biosynthesis of the anthracycline antitumor agents daunomycin, adriamycin, and aclacinomycin, the polyketide-derived… Expand
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Highly Cited
2002
Highly Cited
2002
We have cloned and sequenced polyketide synthase (PKS) genes from the aclacinomycin producer Streptomyces galilaeus ATCC 31,615… Expand
Highly Cited
1997
Highly Cited
1997
Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid… Expand
Highly Cited
1996
Highly Cited
1996
The antitumor drug aclacinomycin A was previously shown to inhibit the degradation of ubiquitinated proteins in rabbit… Expand
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Highly Cited
1982
Highly Cited
1982
The generation of hydroxyl free radicals in the system consisting of purified NADPH-cytochrome P-450 reductase and anticancer… Expand
Highly Cited
1979
Highly Cited
1979
The binding of adriamycin and aclacinomycin A with PM2 DNA, and the consequent cleavage of DNA have been demonstrated by agarose… Expand
Highly Cited
1979
Highly Cited
1979
The structures of aclacinomycins A and B and 19 analogues were determined by a combination of chemical conversions and… Expand
Highly Cited
1979
Highly Cited
1979
Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses… Expand
1979
1979
A phase I study of a new anthracycline antibiotic, aclacinomycin A, was performed in a total of 15 patients with advanced… Expand