aclacinomycin

 
National Institutes of Health

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AclarubicinAclarubicin hydrochloride

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aclacinomycins

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2007
2007
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
Aclacinomycin (Acl) oxidoreductase (AknOx) catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the Acl… (More)
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2005
2005
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
During biosynthesis of the anthracycline antitumor agents daunomycin, adriamycin, and aclacinomycin, the polyketide-derived… (More)
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1997
1997
Aclacinomycin A stabilizes topoisomerase I covalent complexes.
Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid… (More)
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1996
1996
The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome.
The antitumor drug aclacinomycin A was previously shown to inhibit the degradation of ubiquitinated proteins in rabbit… (More)
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1994
1994
Structure by NMR of antitumor drugs aclacinomycin A and B complexed to d(CGTACG).
Aclacinomycins A and B are anthracycline antibiotics with potent antitumor activity. Each consists of an alkavinone aglycon… (More)
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1982
1982
Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase.
The generation of hydroxyl free radicals in the system consisting of purified NADPH-cytochrome P-450 reductase and anticancer… (More)
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1979
1979
Cellular accumulation and disposition of aclacinomycin A.
The cellular accumulation and disposition of the anthracycline antitumor antibiotic aclacinomycin A (ACM) were compared to those… (More)
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1979
1979
DNA strand scission induced by adriamycin and aclacinomycin A.
The binding of adriamycin and aclacinomycin A with PM2 DNA, and the consequent cleavage of DNA have been demonstrated by agarose… (More)
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1979
1979
Clinical study of aclacinomycin A.
A phase I study of a new anthracycline antibiotic, aclacinomycin A, was performed in a total of 15 patients with advanced… (More)
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1978
1978
Clinical experiences with aclacinomycin-A.
Aclacinomycin is a new anthracycline analog of adriamycin and daunomycin. Aclacinomycin contains three sugars. The drug has been… (More)
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