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aclacinomycin

National Institutes of Health

Related topics

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3 relations
AclarubicinAclarubicin hydrochloride

Broader (1)

aclacinomycins

Papers overview

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Highly Cited
2007
Highly Cited
2007
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site
Aclacinomycin (Acl) oxidoreductase (AknOx) catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the Acl… Expand
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Highly Cited
2005
Highly Cited
2005
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
During biosynthesis of the anthracycline antitumor agents daunomycin, adriamycin, and aclacinomycin, the polyketide-derived… Expand
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Highly Cited
2002
Highly Cited
2002
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
We have cloned and sequenced polyketide synthase (PKS) genes from the aclacinomycin producer Streptomyces galilaeus ATCC 31,615… Expand
Highly Cited
1997
Highly Cited
1997
Aclacinomycin A stabilizes topoisomerase I covalent complexes.
Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid… Expand
Highly Cited
1996
Highly Cited
1996
The Antitumor Drug Aclacinomycin A, Which Inhibits the Degradation of Ubiquitinated Proteins, Shows Selectivity for the Chymotrypsin-like Activity of the Bovine Pituitary 20 S Proteasome*
The antitumor drug aclacinomycin A was previously shown to inhibit the degradation of ubiquitinated proteins in rabbit… Expand
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Highly Cited
1982
Highly Cited
1982
Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase.
The generation of hydroxyl free radicals in the system consisting of purified NADPH-cytochrome P-450 reductase and anticancer… Expand
Highly Cited
1979
Highly Cited
1979
DNA strand scission induced by adriamycin and aclacinomycin A.
The binding of adriamycin and aclacinomycin A with PM2 DNA, and the consequent cleavage of DNA have been demonstrated by agarose… Expand
Highly Cited
1979
Highly Cited
1979
Antitumor anthracycline antibiotics, aclacinomycin a and analogues. II. Structural determination.
The structures of aclacinomycins A and B and 19 analogues were determined by a combination of chemical conversions and… Expand
Highly Cited
1979
Highly Cited
1979
Electron microscopic studies of the heart and light microscopic studies of the skin after treatment of golden hamsters with adriamycin, detorubicin, AD-32, and aclacinomycin.
Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses… Expand
1979
1979
Clinical study of aclacinomycin A.
A phase I study of a new anthracycline antibiotic, aclacinomycin A, was performed in a total of 15 patients with advanced… Expand
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