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aclacinomycin

National Institutes of Health

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3 relations
AclarubicinAclarubicin hydrochloride

Broader (1)

aclacinomycins

Papers overview

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Highly Cited
2007
Highly Cited
2007
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site
Aclacinomycin (Acl) oxidoreductase (AknOx) catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the Acl… 
Highly Cited
2006
Highly Cited
2006
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Highly Cited
1997
Highly Cited
1997
Aclacinomycin A stabilizes topoisomerase I covalent complexes.
Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid… 
Highly Cited
1996
Highly Cited
1996
The Antitumor Drug Aclacinomycin A, Which Inhibits the Degradation of Ubiquitinated Proteins, Shows Selectivity for the Chymotrypsin-like Activity of the Bovine Pituitary 20 S Proteasome*
The antitumor drug aclacinomycin A was previously shown to inhibit the degradation of ubiquitinated proteins in rabbit… 
Highly Cited
1994
Highly Cited
1994
Interstrand DNA crosslinking induced by anthracyclines in tumour cells.
Highly Cited
1993
Highly Cited
1993
Molecular modeling: an experimental tool.
The 1920s are sometimes referred to as the "golden age of physics." If recent developments in several other scientific fields are… 
Highly Cited
1990
Highly Cited
1990
Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells.
Highly Cited
1990
Highly Cited
1990
Comparison of the binding of anthracycline derivatives to purified DNA and to cell nuclei.
Highly Cited
1979
Highly Cited
1979
Antitumor anthracycline antibiotics, aclacinomycin a and analogues. II. Structural determination.
The structures of aclacinomycins A and B and 19 analogues were determined by a combination of chemical conversions and… 
Highly Cited
1979
Highly Cited
1979
DNA strand scission induced by adriamycin and aclacinomycin A.
The binding of adriamycin and aclacinomycin A with PM2 DNA, and the consequent cleavage of DNA have been demonstrated by agarose… 
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