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aclacinomycin

 
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Aclacinomycin (Acl) oxidoreductase (AknOx) catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the Acl… Expand
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Highly Cited
2005
Highly Cited
2005
During biosynthesis of the anthracycline antitumor agents daunomycin, adriamycin, and aclacinomycin, the polyketide-derived… Expand
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2004
2004
The antitumor drug aclacinomycin A is a representative member of the anthracycline subgroup that contains a C(7)-O-trisaccharide… Expand
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Highly Cited
2002
Highly Cited
2002
We have cloned and sequenced polyketide synthase (PKS) genes from the aclacinomycin producer Streptomyces galilaeus ATCC 31,615… Expand
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2002
2002
In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We… Expand
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Highly Cited
1997
Highly Cited
1997
Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid… Expand
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Highly Cited
1996
Highly Cited
1996
The antitumor drug aclacinomycin A was previously shown to inhibit the degradation of ubiquitinated proteins in rabbit… Expand
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1994
1994
Twelve mutants of Streptomyces galilaeus (ATCC 31615) blocked in the production of aclacinomycin A, an anthracycline antibiotic… Expand
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1982
1982
The generation of hydroxyl free radicals in the system consisting of purified NADPH-cytochrome P-450 reductase and anticancer… Expand
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1979
1979
The structures of aclacinomycins A and B and 19 analogues were determined by a combination of chemical conversions and… Expand
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